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    sel-1 S5 DRBM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179720, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sel-1
    Official Full Name
    S5 DRBM domain-containing protein
    Primary source
    WormBase:WBGene00004759
    Locus tag
    CELE_F45D3.5
    See related
    AllianceGenome:WB:WBGene00004759
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to contribute to ubiquitin-protein transferase activity. Involved in negative regulation of Notch signaling pathway. Located in cytoplasmic vesicle. Is expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P6.p hermaphrodite; and P7.p hermaphrodite. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to several human genes including SEL1L (SEL1L adaptor subunit of SYVN1 ubiquitin ligase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sel-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (12560732..12563383)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Small ribosomal subunit protein uS5m Neighboring gene Secreted protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cross-species conservation of SEL1L, a human pancreas-specific expressing gene. Biunno I, et al. OMICS, 2002. PMID 12143964
    2. Distinct populations of primary and secondary effectors during RNAi in C. elegans. Pak J, et al. Science, 2007 Jan 12. PMID 17124291
    3. Targeting EDEM protects against ER stress and improves development and survival in C. elegans. Ghenea S, et al. PLoS Genet, 2022 Feb. PMID 35192599, Free PMC Article
    4. SEL1L expression decreases breast tumor cell aggressiveness in vivo and in vitro. Orlandi R, et al. Cancer Res, 2002 Jan 15. PMID 11809711
    5. C. elegans expressing D76N β(2)-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis. Faravelli G, et al. Sci Rep, 2019 Dec 27. PMID 31882874, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    contributes_to ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in IRE1-mediated unfolded protein response HEP PubMed 
    involved_in negative regulation of Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Hrd1p ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    S5 DRBM domain-containing protein
    NP_506144.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12560732..12563383
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073743.8 → NP_506144.1  S5 DRBM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506144.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFG0, Q17378
      Conserved Domains (4) summary
      smart00671
      Location:363 → 398
      SEL1; Sel1-like repeats
      COG0790
      Location:264 → 473
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:309 → 338
      SLR; SLR repeat [structural motif]
      cl01709
      Location:317 → 411
      PBP2_NikA_DppA_OppA_like; The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold
    Nucleotide Protein
    Heading Accession and Version

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