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    sec-15 Exocyst complex component 6 [ Caenorhabditis elegans ]

    Gene ID: 181131, updated on 4-Jan-2025

    Summary

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    Official Symbol
    sec-15
    Official Full Name
    Exocyst complex component 6
    Primary source
    WormBase:WBGene00016188
    Locus tag
    CELE_C28G1.3
    See related
    AllianceGenome:WB:WBGene00016188
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in Golgi to plasma membrane transport and exocytosis. Predicted to be part of exocyst. Is expressed in embryonic cell; excretory canal; and hypodermis. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia with joint laxity type 3. Orthologous to several human genes including EXOC6B (exocyst complex component 6B). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See sec-15 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    12
    Sequence:
    Chromosome: X; NC_003284.9 (8831737..8835715, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene RING-type domain-containing protein Neighboring gene RING-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Glu Neighboring gene Serpin domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RAL-1 controls multivesicular body biogenesis and exosome secretion. Hyenne V, et al. J Cell Biol, 2015 Oct 12. PMID 26459596, Free PMC Article
    2. Polarized exocyst-mediated vesicle fusion directs intracellular lumenogenesis within the C. elegans excretory cell. Armenti ST, et al. Dev Biol, 2014 Oct 1. PMID 25102190, Free PMC Article
    3. Control of E-cadherin apical localisation and morphogenesis by a SOAP-1/AP-1/clathrin pathway in C. elegans epidermal cells. Gillard G, et al. Development, 2015 May 1. PMID 25858456
    4. RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans. Frische EW, et al. EMBO J, 2007 Dec 12. PMID 17989692, Free PMC Article
    5. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle tethering involved in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exocyst ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Exocyst complex component 6
    NP_509496.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8831737..8835715 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077095.10 → NP_509496.3  Exocyst complex component 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509496.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18286
      Conserved Domains (1) summary
      pfam04091
      Location:477 → 783
      Sec15; Exocyst complex subunit Sec15-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18286.4

    Gene LinkOut

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