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    eea-1 FYVE-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179832, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eea-1
    Official Full Name
    FYVE-type domain-containing protein
    Primary source
    WormBase:WBGene00011696
    Locus tag
    CELE_T10G3.5
    See related
    AllianceGenome:WB:WBGene00011696
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables phosphatidylinositol-3-phosphate binding activity. Involved in endocytosis. Located in early endosome and endocytic vesicle. Is expressed in hypodermis and intestine. Orthologous to human EEA1 (early endosome antigen 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See eea-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    11
    Sequence:
    Chromosome: V; NC_003283.11 (13491067..13497372, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class E (Epsilon);Serpentine Receptor, class T Neighboring gene Abnormal cell migration protein 18-like fibronectin type I domain-containing protein Neighboring gene U6 snRNA-associated Sm-like protein LSm2 Neighboring gene Ig-like domain-containing protein;Neurotransmitter-gated ion-channel transmembrane domain-containing protein Neighboring gene FIP (Fungus-Induced Protein) Related

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Asymmetry of early endosome distribution in C. elegans embryos. Andrews R, et al. PLoS One, 2007 Jun 6. PMID 17551574, Free PMC Article
    2. Membrane transport in Caenorhabditis elegans: an essential role for VPS34 at the nuclear membrane. Roggo L, et al. EMBO J, 2002 Apr 2. PMID 11927551, Free PMC Article
    3. Endocytosis function of a ligand-gated ion channel homolog in Caenorhabditis elegans. Patton A, et al. Curr Biol, 2005 Jun 7. PMID 15936276
    4. The C. elegans TspanC8 tetraspanin TSP-14 exhibits isoform-specific localization and function. Liu Z, et al. PLoS Genet, 2022 Jan. PMID 35089916, Free PMC Article
    5. Integrating transcriptomics and behavior tests reveals how the C. elegans responds to copper induced aging. Zhang Y, et al. Ecotoxicol Environ Saf, 2021 Oct 1. PMID 34265532

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SNX-3 mediates retromer-independent tubular endosomal recycling by opposing EEA-1-facilitated trafficking.
      Title: SNX-3 mediates retromer-independent tubular endosomal recycling by opposing EEA-1-facilitated trafficking.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphatidylinositol-3-phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    FYVE-type domain-containing protein
    NP_001024127.1
    • Confirmed by transcript evidence
    NP_001024128.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13491067..13497372 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028956.4 → NP_001024127.1  FYVE-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024127.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ED80
      Conserved Domains (3) summary
      COG1196
      Location:329 → 1077
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:98 → 468
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd15730
      Location:1141 → 1203
      FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins

    2. NM_001028957.5 → NP_001024128.1  FYVE-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024128.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5FC45
      Conserved Domains (3) summary
      COG1196
      Location:327 → 1075
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:96 → 466
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd15730
      Location:1139 → 1201
      FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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