mmcm-1 putative methylmalonyl-CoA mutase, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mmcm-1
Official Full Name: putative methylmalonyl-CoA mutase, mitochondrial
Primary source: WormBase:WBGene00014202
Locus tag: CELE_ZK1058.1
See related: AllianceGenome:WB:WBGene00014202
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables methylmalonyl-CoA mutase activity. Involved in amino acid metabolic process and fatty acid metabolic process. Located in mitochondrion. Used to study methylmalonic acidemia. Human ortholog(s) of this gene implicated in methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency. Orthologous to human MMUT (methylmalonyl-CoA mutase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mmcm-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 6

Sequence:: Chromosome: III; NC_003281.10 (3903185..3907687, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK1058.1 (e-PCR)
- UniSTS:308243

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables cobalamin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cobalamin binding	IEA Inferred from Electronic Annotation more info
enables intramolecular transferase activity	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methylmalonyl-CoA mutase activity	IBA Inferred from Biological aspect of Ancestor more info
enables methylmalonyl-CoA mutase activity	IEA Inferred from Electronic Annotation more info
enables methylmalonyl-CoA mutase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in amino acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in propionate metabolic process, methylmalonyl pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative methylmalonyl-CoA mutase, mitochondrial

NP_497786.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

3903185..3907687 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065385.8 → NP_497786.2 putative methylmalonyl-CoA mutase, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497786.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23381

Conserved Domains (3) summary

TIGR00640
Location:604 → 734

acid_CoA_mut_C; methylmalonyl-CoA mutase C-terminal domain

PRK09426
Location:32 → 737

PRK09426; methylmalonyl-CoA mutase; Reviewed

cd03679
Location:30 → 565

MM_CoA_mutase_alpha_like; Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain ...