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    pir-2 TYR_PHOSPHATASE_2 domain-containing protein;putative tyrosine-protein phosphatase F54C8.4 [ Caenorhabditis elegans ]

    Gene ID: 176323, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pir-2
    Official Full Name
    TYR_PHOSPHATASE_2 domain-containing protein;putative tyrosine-protein phosphatase F54C8.4
    Primary source
    WormBase:WBGene00010037
    Locus tag
    CELE_F54C8.4
    See related
    AllianceGenome:WB:WBGene00010037
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable polynucleotide 5'-phosphatase activity. Predicted to be involved in protein dephosphorylation. Is expressed in AB and pharynx. Orthologous to human DUSP11 (dual specificity phosphatase 11). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pir-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (9441557..9443634, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Histone H3-like centromeric protein cpar-1 Neighboring gene Abnormal embryogenesis protein 30 Neighboring gene putative 3-hydroxyacyl-CoA dehydrogenase F54C8.1 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An RNA 5'-triphosphatase related to the protein tyrosine phosphatases. Takagi T, et al. Cell, 1997 Jun 13. PMID 9200605
    2. A novel, essential trans-splicing protein connects the nematode SL1 snRNP to the CBC-ARS2 complex. Fasimoye RY, et al. Nucleic Acids Res, 2022 Jul 22. PMID 35736244, Free PMC Article
    3. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article
    4. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polynucleotide 5'-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TYR_PHOSPHATASE_2 domain-containing protein;putative tyrosine-protein phosphatase F54C8.4
    NP_001254988.1
    • Confirmed by transcript evidence
    NP_001254989.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9441557..9443634 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268059.2 → NP_001254988.1  putative tyrosine-protein phosphatase F54C8.4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254988.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34442
      Conserved Domains (1) summary
      cl21483
      Location:66 → 166
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    2. NM_001268060.3 → NP_001254989.1  TYR_PHOSPHATASE_2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254989.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1B6R1
      Conserved Domains (1) summary
      cl28904
      Location:1 → 96
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34442.1

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