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    lrp-2 EGF-like domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171981, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lrp-2
    Official Full Name
    EGF-like domain-containing protein
    Primary source
    WormBase:WBGene00003072
    Locus tag
    CELE_T21E3.3
    See related
    AllianceGenome:WB:WBGene00003072
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in regulation of cell migration. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including excretory cell; intestine; nervous system; pharynx; and reproductive system. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lrp-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    20
    Sequence:
    Chromosome: I; NC_003279.8 (3935272..3953991, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Inactive protein-tyrosine phosphatase egg-4 Neighboring gene ncRNA Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Low-Density Lipoprotein Receptor LRP-2 regulates GLR-1 glutamate receptors and glutamatergic behavior in C. elegans. Rennich BJ, et al. MicroPubl Biol, 2023. PMID 37179968, Free PMC Article
    2. Low density lipoprotein receptors LRP-1 and LRP-2 in C. elegans. Minor P, et al. MicroPubl Biol, 2019 Aug 27. PMID 32550404, Free PMC Article
    3. LRP-2 likely acts downstream of EGL-20/Wnt. Minor P, et al. MicroPubl Biol, 2019 Aug 27. PMID 32550422, Free PMC Article
    4. The role of lrp-2 in C. elegans vulval cell lineage polarity. Minor P, et al. MicroPubl Biol, 2019 Aug 27. PMID 32550414, Free PMC Article
    5. New genetic regulators question relevance of abundant yolk protein production in C. elegans. Van Rompay L, et al. Sci Rep, 2015 Nov 10. PMID 26553710, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    EGF-like domain-containing protein
    NP_491270.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3935272..3953991 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058869.5 → NP_491270.2  EGF-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491270.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01768
      Conserved Domains (5) summary
      smart00192
      Location:3481 → 3514
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:1421 → 1463
      LY; Low-density lipoprotein-receptor YWTD domain
      cd00112
      Location:3659 → 3693
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00058
      Location:3296 → 3336
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:1276 → 1305
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    Nucleotide Protein
    Heading Accession and Version

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