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    emr-1 Emerin homolog 1 [ Caenorhabditis elegans ]

    Gene ID: 171752, updated on 9-Dec-2024

    Summary

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    Official Symbol
    emr-1
    Official Full Name
    Emerin homolog 1
    Primary source
    WormBase:WBGene00001309
    Locus tag
    CELE_M01D7.6
    See related
    AllianceGenome:WB:WBGene00001309
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables lamin binding activity. Involved in several processes, including mitotic cytokinesis; nuclear envelope organization; and response to X-ray. Located in nuclear inner membrane. Is expressed in body wall musculature; intestine; nervous system; and pharynx. Used to study Emery-Dreifuss muscular dystrophy. Orthologous to human LEMD1 (LEM domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See emr-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (1842445..1843227)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Guanine nucleotide-binding protein subunit alpha Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Neuropeptide-Like Protein Neighboring gene GHMP kinase C-terminal domain-containing protein;Galactokinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ce-emerin and LEM-2: essential roles in Caenorhabditis elegans development, muscle function, and mitosis. Barkan R, et al. Mol Biol Cell, 2012 Feb. PMID 22171324, Free PMC Article
    2. The expression, lamin-dependent localization and RNAi depletion phenotype for emerin in C. elegans. Gruenbaum Y, et al. J Cell Sci, 2002 Mar 1. PMID 11870211
    3. Transmission electron microscope studies of the nuclear envelope in Caenorhabditis elegans embryos. Cohen M, et al. J Struct Biol, 2002 Oct-Dec. PMID 12490171
    4. Inner nuclear membrane protein LEM-2 is required for correct nuclear separation and morphology in C. elegans. Morales-Martínez A, et al. J Cell Sci, 2015 Mar 15. PMID 25653391
    5. Laminopathic mutations interfere with the assembly, localization, and dynamics of nuclear lamins. Wiesel N, et al. Proc Natl Acad Sci U S A, 2008 Jan 8. PMID 18162544, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We demonstrate a specific role of EMR-1 in neuromuscular junction activity that may contribute to Emery-Dreifuss muscular dystrophy in humans
      Title: Genome-wide analysis links emerin to neuromuscular junction activity in Caenorhabditis elegans.
    2. these results clearly show that Ce-emerin and LEM-2 have additional roles in specific tissues, including striated muscle and smooth muscle.
      Title: Ce-emerin and LEM-2: essential roles in Caenorhabditis elegans development, muscle function, and mitosis.
    3. LEM domain proteins are essential for cell division and that Ce-emerin and Ce-MAN1 share at least one and possibly multiple overlapping functions, which may be relevant to Emery-Dreifuss muscular dystrophy
      Title: MAN1 and emerin have overlapping function(s) essential for chromosome segregation and cell division in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables lamin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nuclear envelope organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to X-ray IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Emerin homolog 1
    NP_490907.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      1842445..1843227
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058506.6 → NP_490907.1  Emerin homolog 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490907.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01971
      Conserved Domains (1) summary
      pfam03020
      Location:2 → 40
      LEM; LEM domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O01971.1

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