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    srp-6 Serpin domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179125, updated on 9-Dec-2024

    Summary

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    Official Symbol
    srp-6
    Official Full Name
    Serpin domain-containing protein
    Primary source
    WormBase:WBGene00005647
    Locus tag
    CELE_C03G6.19
    See related
    AllianceGenome:WB:WBGene00005647
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable peptidase activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in hermaphrodite gonad; intestine; pharyngeal-intestinal valve; socket cell; and vulva. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; Nagashima-type palmoplantar keratosis; autosomal recessive nonsyndromic deafness 91; familial encephalopathy with neuroserpin inclusion bodies; and peeling skin syndrome 5. Orthologous to several human genes including SERPINB1 (serpin family B member 1); SERPINB11 (serpin family B member 11); and SERPINB3 (serpin family B member 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See srp-6 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (7384232..7386102, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene DUF1248 domain-containing protein Neighboring gene pseudo Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene N-acetylgalactosaminide beta-1,3-galactosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A lysosome-targeted fluorescent chemodosimeter for monitoring endogenous and exogenous hydrogen sulfide by in vivo imaging. Zou XJ, et al. Chem Commun (Camb), 2014 Nov 18. PMID 25255077
    2. Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins. Luke CJ, et al. Commun Biol, 2022 Jan 12. PMID 35022507, Free PMC Article
    3. Selective conservation of the RSL-encoding, proteinase inhibitory-type, clade L serpins in Caenorhabditis species. Luke CJ, et al. Front Biosci, 2006 Jan 1. PMID 16146754
    4. SRP-2 is a cross-class inhibitor that participates in postembryonic development of the nematode Caenorhabditis elegans: initial characterization of the clade L serpins. Pak SC, et al. J Biol Chem, 2004 Apr 9. PMID 14739286
    5. Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans. Schiavi A, et al. Exp Gerontol, 2013 Feb. PMID 23247094, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Serpin domain-containing protein
    NP_504890.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      7384232..7386102 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072489.7 → NP_504890.1  Serpin domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504890.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFH4
      Conserved Domains (1) summary
      cd19581
      Location:16 → 374
      serpinL_nematode; serpin family L, serpin family proteins from nematodes
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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