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    Y75B8A.24 1-phosphatidylinositol 4-kinase [ Caenorhabditis elegans ]

    Gene ID: 176653, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y75B8A.24
    Official Full Name
    1-phosphatidylinositol 4-kinase
    Primary source
    WormBase:WBGene00013557
    Locus tag
    CELE_Y75B8A.24
    See related
    AllianceGenome:WB:WBGene00013557
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 1-phosphatidylinositol 4-kinase activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and phosphatidylinositol-mediated signaling. Predicted to be active in cytoplasm and plasma membrane. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 84. Orthologous to several human genes including PI4KA (phosphatidylinositol 4-kinase alpha). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y75B8A.24 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    16
    Sequence:
    Chromosome: III; NC_003281.10 (12251494..12273752, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene RanBD1 domain-containing protein Neighboring gene Multidrug resistance-associated protein 1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. Gottschalk A, et al. EMBO J, 2005 Jul 20. PMID 15990870, Free PMC Article
    2. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol 4-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4-kinase
    NP_499596.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12251494..12273752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067195.6 → NP_499596.2  1-phosphatidylinositol 4-kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499596.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XW63
      Conserved Domains (2) summary
      cd00871
      Location:1544 → 1720
      PI4Ka; Phosphoinositide 4-kinase(PI4K), accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. PI4K phosphorylates hydroxylgroup at position 4 on the ...
      cd05167
      Location:1781 → 2105
      PI4Kc_III_alpha; Catalytic domain of Type III Phosphoinositide 4-kinase alpha
    Nucleotide Protein
    Heading Accession and Version

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