U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PFA-DSP1 Phosphotyrosine protein phosphatases superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839348, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    PFA-DSP1
    Official Full Name
    Phosphotyrosine protein phosphatases superfamily protein
    Primary source
    TAIR:AT1G05000
    Locus tag
    AT1G05000
    See related
    Araport:AT1G05000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtPFA-DSP1; plant and fungi atypical dual-specificity phosphatase 1; T7A14.14; T7A14_14
    Summary
    Encodes an atypical dual-specificity phosphatase.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PFA-DSP1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (1425539..1428869)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene PDI-like 2-2 Neighboring gene triacylglycerol lipase-like protein Neighboring gene Zinc finger C-x8-C-x5-C-x3-H type family protein Neighboring gene PPR containing protein Neighboring gene ncRNA Neighboring gene ethylene-forming enzyme

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A structural exposé of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop. Wang H, et al. Nat Commun, 2022 Apr 25. PMID 35468885, Free PMC Article
    2. Structural and functional characterization of a novel phosphatase from the Arabidopsis thaliana gene locus At1g05000. Aceti DJ, et al. Proteins, 2008 Oct. PMID 18433060, Free PMC Article
    3. Arabidopsis PFA-DSP-Type Phosphohydrolases Target Specific Inositol Pyrophosphate Messengers. Gaugler P, et al. Biochemistry, 2022 Jun 21. PMID 35640071, Free PMC Article
    4. Chloroplast biogenesis is regulated by direct action of the ubiquitin-proteasome system. Ling Q, et al. Science, 2012 Nov 2. PMID 23118188
    5. Phylogenetic and genetic linkage between novel atypical dual-specificity phosphatases from non-metazoan organisms. Romá-Mateo C, et al. Mol Genet Genomics, 2011 Apr. PMID 21409566

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_001160832.2
    NM_100379.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Phosphotyrosine protein phosphatases superfamily protein
    NP_001154304.1
    • Phosphotyrosine protein phosphatases superfamily protein; FUNCTIONS IN: phosphatase activity, protein tyrosine phosphatase activity, phosphoprotein phosphatase activity; INVOLVED IN: dephosphorylation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Protein-tyrosine phosphatase, active site (InterPro:IPR016130), Protein-tyrosine phosphatase, dual specificity phosphatase, eukaryotic (InterPro:IPR020428), Protein-tyrosine phosphatase, SIW14-like (InterPro:IPR004861); BEST Arabidopsis thaliana protein match is: Phosphotyrosine protein phosphatases superfamily protein (TAIR:AT2G32960.1); Has 580 Blast hits to 572 proteins in 119 species: Archae - 0; Bacteria - 14; Metazoa - 1; Fungi - 314; Plants - 145; Viruses - 0; Other Eukaryotes - 106 (source: NCBI BLink).
    NP_171993.1
    • Phosphotyrosine protein phosphatases superfamily protein; FUNCTIONS IN: phosphatase activity, protein tyrosine phosphatase activity, phosphoprotein phosphatase activity; INVOLVED IN: dephosphorylation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Protein-tyrosine phosphatase, active site (InterPro:IPR016130), Protein-tyrosine phosphatase, dual specificity phosphatase, eukaryotic (InterPro:IPR020428), Protein-tyrosine phosphatase, SIW14-like (InterPro:IPR004861); BEST Arabidopsis thaliana protein match is: Phosphotyrosine protein phosphatases superfamily protein (TAIR:AT2G32960.1); Has 669 Blast hits to 655 proteins in 149 species: Archae - 0; Bacteria - 50; Metazoa - 4; Fungi - 355; Plants - 145; Viruses - 0; Other Eukaryotes - 115 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      1425539..1428869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001331513.1 → NP_001322400.1  Phosphotyrosine protein phosphatases superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WME5, A0A1P8ATV0

    2. NM_001160832.2 → NP_001154304.1  Phosphotyrosine protein phosphatases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154304.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WMD7, A0A5S9SMT2, F4I780
      Conserved Domains (1) summary
      pfam03162
      Location:53 → 234
      Y_phosphatase2; Tyrosine phosphatase family

    3. NM_100379.3 → NP_171993.1  Phosphotyrosine protein phosphatases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_171993.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WS70, Q9ZVN4
      UniProtKB/TrEMBL
      A0A178WMD7, A0A5S9SMT2
      Conserved Domains (1) summary
      cd14528
      Location:52 → 199
      PFA-DSP_Siw14; atypical dual specificity phosphatases similar to yeast Siw14
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZVN4.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.