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    PDIL5-2 PDI-like 5-2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 840461, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PDIL5-2
    Official Full Name
    PDI-like 5-2
    Primary source
    TAIR:AT1G35620
    Locus tag
    AT1G35620
    See related
    Araport:AT1G35620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA PROTEIN DISULFIDE ISOMERASE 8; ATPDI8; ATPDIL5-2; F15O4.20; PDI-like 5-2; PDI8; PROTEIN DISULFIDE ISOMERASE 8
    Summary
    Encodes a protein disulfide isomerase-like (PDIL) protein, a member of a multigene family within the thioredoxin (TRX) superfamily. Unlike several other PDI family members, transcript levels for this gene are not up-regulated in response to three different chemical inducers of ER stress (dithiothreitol, beta-mercaptoethanol, and tunicamycin). However, the level of transcripts for this gene is slightly elevated in atbzip60 mutants.
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    Genomic context

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    See PDIL5-2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (13156346..13158467)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene RING/U-box superfamily protein Neighboring gene Protease-associated (PA) RING/U-box zinc finger family protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis protein disulfide isomerase-8 is a type I endoplasmic reticulum transmembrane protein with thiol-disulfide oxidase activity. Yuen CY, et al. BMC Plant Biol, 2016 Aug 22. PMID 27549196, Free PMC Article
    2. Endoplasmic reticulum stress activates the expression of a sub-group of protein disulfide isomerase genes and AtbZIP60 modulates the response in Arabidopsis thaliana. Lu DP, et al. Mol Genet Genomics, 2008 Sep. PMID 18574595
    3. Arabidopsis cell wall proteome defined using multidimensional protein identification technology. Bayer EM, et al. Proteomics, 2006 Jan. PMID 16287169
    4. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article
    5. A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell culture. Jaquinod M, et al. Mol Cell Proteomics, 2007 Mar. PMID 17151019, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PDI8 is a type I transmembrane protein with its catalytic domain facing the lumen of the endoplasmic reticulum and functions in the oxidation of cysteines to produce disulfide bonds.
      Title: Arabidopsis protein disulfide isomerase-8 is a type I endoplasmic reticulum transmembrane protein with thiol-disulfide oxidase activity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_103262.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein disulfide isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in plant-type cell wall HDA PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    PDI-like 5-2
    NP_564462.1
    • PDI-like 5-2 (PDIL5-2); FUNCTIONS IN: protein disulfide isomerase activity; INVOLVED IN: cell redox homeostasis; LOCATED IN: endoplasmic reticulum, plasma membrane, plant-type cell wall; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Thioredoxin-like subdomain (InterPro:IPR006662), Thioredoxin-like (InterPro:IPR017936), Thioredoxin domain (InterPro:IPR013766), Thioredoxin-like fold (InterPro:IPR012336), Thioredoxin, conserved site (InterPro:IPR017937); BEST Arabidopsis thaliana protein match is: PDI-like 1-1 (TAIR:AT1G21750.2); Has 16921 Blast hits to 14897 proteins in 2775 species: Archae - 169; Bacteria - 7975; Metazoa - 3273; Fungi - 1120; Plants - 1363; Viruses - 4; Other Eukaryotes - 3017 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      13156346..13158467
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_103262.5 → NP_564462.1  PDI-like 5-2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564462.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94F09, Q9LQG5
      UniProtKB/TrEMBL
      A0A178WDY8
      Conserved Domains (2) summary
      cd02961
      Location:35 → 134
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      TIGR01130
      Location:34 → 327
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94F09.1

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