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    TSA1 TSK-associating protein 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841671, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TSA1
    Official Full Name
    TSK-associating protein 1
    Primary source
    TAIR:AT1G52410
    Locus tag
    AT1G52410
    See related
    Araport:AT1G52410
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtTSA1; F19K6.14; F19K6_14; TSK-associating protein 1
    Summary
    Contains a novel calcium-binding repeat sequence. Binds TSK in vitro. Localizes to small cytoplasmic vesicles in interphase cells. In cells synchronized for cell division, TSA1 and TSK relocalize to ends of spindle microtubules that are ahead of separating chromatids during metaphase and anaphase of mitosis. May be involved in mitosis together with TSK. Expressed preferentially in the flower and shoot apex. Can form multimers.
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    Genomic context

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    See TSA1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    26
    Sequence:
    Chromosome: 1; NC_003070.9 (19520603..19525685)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene beta glucosidase 18 Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene UDP-Glycosyltransferase superfamily protein Neighboring gene Ubiquitin carboxyl-terminal hydrolase-related protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An Arabidopsis protein with a novel calcium-binding repeat sequence interacts with TONSOKU/MGOUN3/BRUSHY1 involved in meristem maintenance. Suzuki T, et al. Plant Cell Physiol, 2005 Sep. PMID 15964904
    2. TSA1 interacts with CSN1/CSN and may be functionally involved in Arabidopsis seedling development in darkness. Li W, et al. J Genet Genomics, 2011 Nov 20. PMID 22133685
    3. At14a-Like1 participates in membrane-associated mechanisms promoting growth during drought in Arabidopsis thaliana. Kumar MN, et al. Proc Natl Acad Sci U S A, 2015 Aug 18. PMID 26240315, Free PMC Article
    4. Proteome analysis of peroxisomes from dark-treated senescent Arabidopsis leaves. Pan R, et al. J Integr Plant Biol, 2018 Nov. PMID 29877633
    5. Disease-specific expression of host genes during downy mildew infection of Arabidopsis. Huibers RP, et al. Mol Plant Microbe Interact, 2009 Sep. PMID 19656045

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TSA1 interacts with CSN1 and is involved in Arabidopsis seedling development in darkness.
      Title: TSA1 interacts with CSN1/CSN and may be functionally involved in Arabidopsis seedling development in darkness.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_104119.3
    NM_179466.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to fungus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within photomorphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast thylakoid membrane HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in peroxisome HDA PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in secretory vesicle HDA PubMed 

    General protein information

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    Preferred Names
    TSK-associating protein 1
    NP_564607.1
    • TSK-associating protein 1 (TSA1); FUNCTIONS IN: protein binding, calcium ion binding; INVOLVED IN: response to salt stress, defense response to fungus; LOCATED IN: chloroplast thylakoid membrane, peroxisome, vacuole; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 12 growth stages; BEST Arabidopsis thaliana protein match is: DNA topoisomerase-related (TAIR:AT3G15950.1); Has 59847 Blast hits to 38717 proteins in 2386 species: Archae - 776; Bacteria - 9580; Metazoa - 25390; Fungi - 6405; Plants - 3006; Viruses - 316; Other Eukaryotes - 14374 (source: NCBI BLink).
    NP_849797.1
    • TSK-associating protein 1 (TSA1); FUNCTIONS IN: protein binding, calcium ion binding; INVOLVED IN: response to salt stress, defense response to fungus; LOCATED IN: chloroplast thylakoid membrane, peroxisome, vacuole; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 12 growth stages; BEST Arabidopsis thaliana protein match is: DNA topoisomerase-related (TAIR:AT3G15950.1); Has 60400 Blast hits to 39040 proteins in 2421 species: Archae - 836; Bacteria - 9681; Metazoa - 25540; Fungi - 6572; Plants - 3009; Viruses - 263; Other Eukaryotes - 14499 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      19520603..19525685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179466.3 → NP_849797.1  TSK-associating protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849797.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4ICX9, F4ICY0, Q94AE1, Q9C831
      UniProtKB/TrEMBL
      A0A5S9WR38
      Conserved Domains (1) summary
      PTZ00121
      Location:128 → 495
      PTZ00121; MAEBL; Provisional

    2. NM_104119.3 → NP_564607.1  TSK-associating protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564607.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9WR38
      Conserved Domains (1) summary
      COG1196
      Location:118 → 429
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4ICX9.1

    Gene LinkOut

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