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    GYRA DNA GYRASE A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820238, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GYRA
    Official Full Name
    DNA GYRASE A
    Primary source
    TAIR:AT3G10690
    Locus tag
    AT3G10690
    See related
    Araport:AT3G10690
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DNA GYRASE A; T7M13.23
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    Genomic context

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    See GYRA in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    27
    Sequence:
    Chromosome: 3; NC_003074.8 (3339392..3346360, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene non-intrinsic ABC protein 7 Neighboring gene HSP20-like chaperones superfamily protein Neighboring gene galacturonic acid kinase Neighboring gene root hair specific 12

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DNA Gyrase Is the Target for the Quinolone Drug Ciprofloxacin in Arabidopsis thaliana. Evans-Roberts KM, et al. J Biol Chem, 2016 Feb 12. PMID 26663076, Free PMC Article
    2. Arabidopsis thaliana DNA gyrase is targeted to chloroplasts and mitochondria. Wall MK, et al. Proc Natl Acad Sci U S A, 2004 May 18. PMID 15136745, Free PMC Article
    3. Arabidopsis thaliana GYRB3 does not encode a DNA gyrase subunit. Evans-Roberts KM, et al. PLoS One, 2010 Mar 26. PMID 20360860, Free PMC Article
    4. pTAC2, -6, and -12 are components of the transcriptionally active plastid chromosome that are required for plastid gene expression. Pfalz J, et al. Plant Cell, 2006 Jan. PMID 16326926, Free PMC Article
    5. Purification of a plant mediator from Arabidopsis thaliana identifies PFT1 as the Med25 subunit. Bäckström S, et al. Mol Cell, 2007 Jun 8. PMID 17560376

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_111905.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    contributes_to DNA negative supercoiling activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA topoisomerase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA topological change IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast nucleoid HDA PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    DNA GYRASE A
    NP_187680.2
    • DNA GYRASE A (GYRA); FUNCTIONS IN: DNA topoisomerase activity, catalytic activity, ATP binding; INVOLVED IN: DNA topological change, DNA metabolic process; LOCATED IN: mitochondrion, chloroplast, nucleoid; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA gyrase, subunit A (InterPro:IPR005743), DNA topoisomerase, type IIA, subunit A/C-terminal (InterPro:IPR002205), DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta (InterPro:IPR013758), DNA topoisomerase, type IIA, subunit A, alpha-helical (InterPro:IPR013757), DNA topoisomerase, type IIA, central (InterPro:IPR013760), DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel (InterPro:IPR006691); BEST Arabidopsis thaliana protein match is: topoisomerase II (TAIR:AT3G23890.1); Has 22353 Blast hits to 21396 proteins in 3265 species: Archae - 84; Bacteria - 12907; Metazoa - 182; Fungi - 204; Plants - 111; Viruses - 99; Other Eukaryotes - 8766 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      3339392..3346360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111905.3 → NP_187680.2  DNA GYRASE A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187680.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9CAF6, Q9SG75
      UniProtKB/TrEMBL
      A0A178VFQ6, A0A178VFU0, A0A5S9XB41
      Conserved Domains (2) summary
      PRK05560
      Location:97 → 932
      PRK05560; DNA gyrase subunit A; Validated
      sd00041
      Location:600 → 647
      GyrA-ParC_C; GyrA_CTD repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CAF6.2

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