C2 Calcium-dependent lipid-binding (CaLB domain) family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: C2
Official Full Name: Calcium-dependent lipid-binding (CaLB domain) family protein
Primary source: TAIR:AT3G17980
Locus tag: AT3G17980
See related: Araport:AT3G17980
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: Arabidopsis thaliana C2 domain; AtC2; AtGAP1; C2 domain; homolog of OsGAP1
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Genomic context

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See C2 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 4

Sequence:: Chromosome: 3; NC_003074.8 (6152062..6153814)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CARs are peripheral membrane proteins that functionally cluster on the membrane and generate strong positive membrane curvature in a Ca(2+)-dependent manner.[CAR4]
Title: Calcium-dependent oligomerization of CAR proteins at cell membrane modulates ABA signaling.
crystals of AT3G17980 diffracted to 2.2 A resolution and belonged to space group P2(1)2(1)2(1), with unit-cell parameters a = 35.3, b = 88.9, c = 110.6 A
Title: Crystallization and preliminary crystallographic analysis of a C2 protein from Arabidopsis thaliana.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_112679.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables phospholipid binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of abscisic acid-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of defense response to bacterium	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of response to salt stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to salt stress	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Calcium-dependent lipid-binding (CaLB domain) family protein

NP_188425.2

Calcium-dependent lipid-binding (CaLB domain) family protein; CONTAINS InterPro DOMAIN/s: C2 membrane targeting protein (InterPro:IPR018029), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), C2 calcium-dependent membrane targeting (InterPro:IPR000008); BEST Arabidopsis thaliana protein match is: Calcium-dependent lipid-binding (CaLB domain) family protein (TAIR:AT1G48590.2); Has 4930 Blast hits to 4266 proteins in 254 species: Archae - 0; Bacteria - 0; Metazoa - 2771; Fungi - 648; Plants - 1093; Viruses - 0; Other Eukaryotes - 418 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

6152062..6153814

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_112679.4 → NP_188425.2 Calcium-dependent lipid-binding (CaLB domain) family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_188425.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LVH4

UniProtKB/TrEMBL

A0A178VF91, A0A5S9XDE1

Conserved Domains (1) summary

cd04038
Location:17 → 160

C2_ArfGAP; C2 domain present in Arf GTPase Activating Proteins (GAP)