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    PPOX Flavin containing amine oxidoreductase family [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827991, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PPOX
    Official Full Name
    Flavin containing amine oxidoreductase family
    Primary source
    TAIR:AT4G01690
    Locus tag
    AT4G01690
    See related
    Araport:AT4G01690
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    HEMG1; PPO1; PROTOPORPHYRINOGEN OXIDASE
    Summary
    Encodes protoporphyrinogen oxidase (PPOX).
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    Genomic context

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    See PPOX in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    9
    Sequence:
    Chromosome: 4; NC_003075.7 (729863..732433)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene myb domain protein 55 Neighboring gene Chitinase family protein Neighboring gene ncRNA Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of a cDNA that encodes protoporphyrinogen oxidase of Arabidopsis thaliana. Narita S, et al. Gene, 1996 Dec 5. PMID 8982084
    2. Two isoforms of Arabidopsis protoporphyrinogen oxidase localize in different plastidal membranes. Hedtke B, et al. Plant Physiol, 2023 May 31. PMID 36806676, Free PMC Article
    3. Tetrapyrrole biosynthetic enzyme protoporphyrinogen IX oxidase 1 is required for plastid RNA editing. Zhang F, et al. Proc Natl Acad Sci U S A, 2014 Feb 4. PMID 24497494, Free PMC Article
    4. Proteomic study of the Arabidopsis thaliana chloroplastic envelope membrane utilizing alternatives to traditional two-dimensional electrophoresis. Froehlich JE, et al. J Proteome Res, 2003 Jul-Aug. PMID 12938931
    5. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two isoforms of Arabidopsis protoporphyrinogen oxidase localize in different plastidal membranes.
      Title: Two isoforms of Arabidopsis protoporphyrinogen oxidase localize in different plastidal membranes.
    2. The tetrapyrrole biosynthetic enzyme PPO1 is required for plastid RNA editing.
      Title: Tetrapyrrole biosynthetic enzyme protoporphyrinogen IX oxidase 1 is required for plastid RNA editing.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_116399.4
    NM_178952.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables oxygen-dependent protoporphyrinogen oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxygen-dependent protoporphyrinogen oxidase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chlorophyll biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within porphyrin-containing compound biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protoporphyrinogen IX biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast thylakoid HDA PubMed 
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    Flavin containing amine oxidoreductase family
    NP_192078.1
    • PPOX; FUNCTIONS IN: oxygen-dependent protoporphyrinogen oxidase activity; INVOLVED IN: porphyrin biosynthetic process; LOCATED IN: chloroplast, chloroplast envelope; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Amine oxidase (InterPro:IPR002937), Protoporphyrinogen oxidase (InterPro:IPR004572); BEST Arabidopsis thaliana protein match is: Flavin containing amine oxidoreductase family (TAIR:AT5G14220.1); Has 2258 Blast hits to 2244 proteins in 787 species: Archae - 6; Bacteria - 1416; Metazoa - 200; Fungi - 137; Plants - 154; Viruses - 0; Other Eukaryotes - 345 (source: NCBI BLink).
    NP_849283.1
    • PPOX; FUNCTIONS IN: oxygen-dependent protoporphyrinogen oxidase activity; INVOLVED IN: porphyrin biosynthetic process; LOCATED IN: chloroplast, chloroplast envelope; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Amine oxidase (InterPro:IPR002937), Protoporphyrinogen oxidase (InterPro:IPR004572); BEST Arabidopsis thaliana protein match is: Flavin containing amine oxidoreductase family (TAIR:AT5G14220.1); Has 2189 Blast hits to 2187 proteins in 783 species: Archae - 6; Bacteria - 1392; Metazoa - 195; Fungi - 135; Plants - 152; Viruses - 0; Other Eukaryotes - 309 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      729863..732433
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116399.4 → NP_192078.1  Flavin containing amine oxidoreductase family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192078.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JG44, P55826, Q5M730, Q94F25, Q9ZSI5
      UniProtKB/TrEMBL
      A0A178UVN5, A0A5S9XPT5, A0A654FL98
      Conserved Domains (1) summary
      PLN02576
      Location:45 → 537
      PLN02576; protoporphyrinogen oxidase

    2. NM_178952.2 → NP_849283.1  Flavin containing amine oxidoreductase family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849283.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FL98
      Conserved Domains (2) summary
      PLN02576
      Location:45 → 506
      PLN02576; protoporphyrinogen oxidase
      pfam13450
      Location:61 → 122
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55826.1

    Gene LinkOut

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