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    FMN/FHY riboflavin kinase/FMN hydrolase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828232, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FMN/FHY
    Official Full Name
    riboflavin kinase/FMN hydrolase
    Primary source
    TAIR:AT4G21470
    Locus tag
    AT4G21470
    See related
    Araport:AT4G21470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATFMN/FHY; F18E5.90; F18E5_90; riboflavin kinase/FMN hydrolase
    Summary
    Bifunctional enzyme that catalyzes hydrolysis of FMN to riboflavin, and phosphorylation of riboflavin to FMN.
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    Genomic context

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    See FMN/FHY in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    10
    Sequence:
    Chromosome: 4; NC_003075.7 (11431104..11433322)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene PapD-like superfamily protein Neighboring gene Ribosomal protein S24/S35 Neighboring gene sugar transporter protein 12 Neighboring gene NAD(P)H dehydrogenase B3 Neighboring gene ncRNA Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An FMN hydrolase is fused to a riboflavin kinase homolog in plants. Sandoval FJ, et al. J Biol Chem, 2005 Nov 18. PMID 16183635
    2. Differential binding of calmodulin-related proteins to their targets revealed through high-density Arabidopsis protein microarrays. Popescu SC, et al. Proc Natl Acad Sci U S A, 2007 Mar 13. PMID 17360592, Free PMC Article
    3. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_118267.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables FMN adenylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables riboflavin kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in FMN biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in riboflavin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    riboflavin kinase/FMN hydrolase
    NP_193878.2
    • riboflavin kinase/FMN hydrolase (FMN/FHY); FUNCTIONS IN: riboflavin kinase activity, FMN adenylyltransferase activity; INVOLVED IN: riboflavin biosynthetic process, metabolic process; LOCATED IN: endomembrane system; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), Haloacid dehydrogenase/epoxide hydrolase (InterPro:IPR005833), Riboflavin kinase (InterPro:IPR015865), HAD-superfamily hydrolase, subfamily IA, variant 3 (InterPro:IPR006402); BEST Arabidopsis thaliana protein match is: Haloacid dehalogenase-like hydrolase (HAD) superfamily protein (TAIR:AT5G57440.1); Has 19964 Blast hits to 19956 proteins in 2653 species: Archae - 146; Bacteria - 15844; Metazoa - 398; Fungi - 526; Plants - 433; Viruses - 3; Other Eukaryotes - 2614 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      11431104..11433322
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118267.5 → NP_193878.2  riboflavin kinase/FMN hydrolase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193878.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65412, Q84MD8
      UniProtKB/TrEMBL
      A0A178V341, A0A5S9XVC6, A0A654FRF1
      Conserved Domains (1) summary
      PLN02940
      Location:1 → 379
      PLN02940; riboflavin kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84MD8.1

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