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    GTR2 Major facilitator superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836389, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GTR2
    Official Full Name
    Major facilitator superfamily protein
    Primary source
    TAIR:AT5G62680
    Locus tag
    AT5G62680
    See related
    Araport:AT5G62680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtNPF2.11; GLUCOSINOLATE TRANSPORTER-2; MRG21.10; MRG21_10; NPF2.11; NRT1/ PTR family 2.11
    Summary
    Encodes a high-affinity, proton-dependent glucosinolate-specific transporter that is crucial for the transport of both methionine- and tryptophan-derived glucosinolates to seeds.
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    Genomic context

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    See GTR2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (25165137..25168060, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene ncRNA Neighboring gene H[+]-ATPase 11 Neighboring gene tubulin beta chain 2 Neighboring gene tubulin beta chain 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Functional EXXEK Motif is Essential for Proton Coupling and Active Glucosinolate Transport by NPF2.11. Jørgensen ME, et al. Plant Cell Physiol, 2015 Dec. PMID 26443378, Free PMC Article
    2. Rhizosecretion of stele-synthesized glucosinolates and their catabolites requires GTR-mediated import in Arabidopsis. Xu D, et al. J Exp Bot, 2017 Jun 1. PMID 27702989, Free PMC Article
    3. Elucidating the role of transport processes in leaf glucosinolate distribution. Madsen SR, et al. Plant Physiol, 2014 Nov. PMID 25209984, Free PMC Article
    4. Upon bolting the GTR1 and GTR2 transporters mediate transport of glucosinolates to the inflorescence rather than roots. Andersen TG, et al. Plant Signal Behav, 2014. PMID 24481282, Free PMC Article
    5. NRT/PTR transporters are essential for translocation of glucosinolate defence compounds to seeds. Nour-Eldin HH, et al. Nature, 2012 Aug 23. PMID 22864417

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of glucosinolate (GLS) importers GTR1 and GTR2 inside the stele, along with earlier observations, suggest three possible routes of stele-synthesized aliphatic GLS after their synthesis: (i) GTR-dependent import to cells symplastically connected to cortical cells and rhizosphere; (ii) GTR-independent transport via xylem to the shoot; and (iii) GTR-dependent import to GLS-degrading myrosin cells at the cortex.
      Title: Rhizosecretion of stele-synthesized glucosinolates and their catabolites requires GTR-mediated import in Arabidopsis.
    2. Study demonstrates an essential role for E1X1X2E2K motif for accumulation of substrate by NPF2.11. [NPF2.11]
      Title: A Functional EXXEK Motif is Essential for Proton Coupling and Active Glucosinolate Transport by NPF2.11.
    3. GTR2 role of transport processes in leaf glucosinolate distribution
      Title: Elucidating the role of transport processes in leaf glucosinolate distribution.
    4. glucosinolate can specifically translocate from rosette and roots to inflorescence in a GTR1- and GTR2-dependent manner
      Title: Upon bolting the GTR1 and GTR2 transporters mediate transport of glucosinolates to the inflorescence rather than roots.
    5. GTR1 and GTR2 control the loading of glucosinolates from the apoplasm into the phloem. [GTR2]
      Title: NRT/PTR transporters are essential for translocation of glucosinolate defence compounds to seeds.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_125663.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables glucosinolate:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within glucosinolate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glucosinolate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within phloem glucosinolate loading IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    Major facilitator superfamily protein
    NP_201074.1
    • Major facilitator superfamily protein; FUNCTIONS IN: transporter activity; INVOLVED IN: oligopeptide transport, response to karrikin; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Oligopeptide transporter (InterPro:IPR000109), Major facilitator superfamily, general substrate transporter (InterPro:IPR016196); BEST Arabidopsis thaliana protein match is: Major facilitator superfamily protein (TAIR:AT3G47960.1); Has 3769 Blast hits to 3614 proteins in 562 species: Archae - 0; Bacteria - 609; Metazoa - 518; Fungi - 366; Plants - 2162; Viruses - 0; Other Eukaryotes - 114 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      25165137..25168060 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125663.4 → NP_201074.1  Major facilitator superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201074.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LV10
      UniProtKB/TrEMBL
      A0A178UEQ7, A0A5S9YGD8
      Conserved Domains (1) summary
      cd17416
      Location:50 → 589
      MFS_NPF1_2; NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LV10.1

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