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    FPS2 farnesyl diphosphate synthase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827430, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FPS2
    Official Full Name
    farnesyl diphosphate synthase 2
    Primary source
    TAIR:AT4G17190
    Locus tag
    AT4G17190
    See related
    Araport:AT4G17190
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DL4630C; farnesyl diphosphate synthase 2; FARNESYL DIPHOSPHATE SYNTHASE 2; FCAALL.91
    Summary
    Encodes a protein with farnesyl diphosphate synthase activity, which catalyzes the rate limiting step in isoprenoid biosynthesis. Its mRNA is most abundantly expressed in flowers.
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    Genomic context

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    See FPS2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    10
    Sequence:
    Chromosome: 4; NC_003075.7 (9648467..9650912, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene RAB GTPase homolog B1C Neighboring gene O-Glycosyl hydrolases family 17 protein Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene weak chloroplast movement under blue light protein (DUF827)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aphid-repellent pheromone E-β-farnesene is generated in transgenic Arabidopsis thaliana over-expressing farnesyl diphosphate synthase2. Bhatia V, et al. Ann Bot, 2015 Mar. PMID 25538111, Free PMC Article
    2. Arabidopsis thaliana contains two differentially expressed farnesyl-diphosphate synthase genes. Cunillera N, et al. J Biol Chem, 1996 Mar 29. PMID 8631820
    3. Suppressing Farnesyl Diphosphate Synthase Alters Chloroplast Development and Triggers Sterol-Dependent Induction of Jasmonate- and Fe-Related Responses. Manzano D, et al. Plant Physiol, 2016 Sep. PMID 27382138, Free PMC Article
    4. Characterization of Arabidopsis FPS isozymes and FPS gene expression analysis provide insight into the biosynthesis of isoprenoid precursors in seeds. Keim V, et al. PLoS One, 2012. PMID 23145086, Free PMC Article
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Farnesyl diphosphate synthase (FPS) single fps1 and fps2 knockout mutants are phenotypically indistinguishable from wild-type plants, while fps1/fps2 double mutants are embryo lethal.
      Title: Suppressing Farnesyl Diphosphate Synthase Alters Chloroplast Development and Triggers Sterol-Dependent Induction of Jasmonate- and Fe-Related Responses.
    2. Over-expression of FPS2 in the cytosol and targeting of its translated product to chloroplasts in arabidopsis led to synthesis of several novel sesquiterpenes, including E-beta-farnesene, and induced alarm responses in Myzus persicae.
      Title: Aphid-repellent pheromone E-β-farnesene is generated in transgenic Arabidopsis thaliana over-expressing farnesyl diphosphate synthase2.
    3. Expression analysis of FPS genes in seeds showed that FPS1 and FPS2 display complementary patterns of expression particularly at late stages of seed development, which suggests that Arabidopsis seeds have two spatially segregated sources of FPP
      Title: Characterization of Arabidopsis FPS isozymes and FPS gene expression analysis provide insight into the biosynthesis of isoprenoid precursors in seeds.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_001341194.1
    NM_117823.4
    NM_202836.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables dimethylallyltranstransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dimethylallyltranstransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables geranyltranstransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables geranyltranstransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables transferase activity, transferring alkyl or aryl (other than methyl) groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within farnesyl diphosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in farnesyl diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within farnesyl diphosphate biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in geranyl diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    farnesyl diphosphate synthase 2
    NP_193452.1
    • farnesyl diphosphate synthase 2 (FPS2); CONTAINS InterPro DOMAIN/s: Terpenoid synthase (InterPro:IPR008949), Polyprenyl synthetase (InterPro:IPR000092); BEST Arabidopsis thaliana protein match is: farnesyl diphosphate synthase 1 (TAIR:AT5G47770.1); Has 5842 Blast hits to 5835 proteins in 1891 species: Archae - 198; Bacteria - 3613; Metazoa - 226; Fungi - 204; Plants - 214; Viruses - 0; Other Eukaryotes - 1387 (source: NCBI BLink).
    NP_974565.1
    • farnesyl diphosphate synthase 2 (FPS2); CONTAINS InterPro DOMAIN/s: Terpenoid synthase (InterPro:IPR008949), Polyprenyl synthetase (InterPro:IPR000092); BEST Arabidopsis thaliana protein match is: farnesyl diphosphate synthase 1 (TAIR:AT5G47770.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      9648467..9650912 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117823.4 → NP_193452.1  farnesyl diphosphate synthase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193452.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q43315
      UniProtKB/TrEMBL
      A0A178UUX8, A0A5S9XT96, A0A7G2F1F7
      Conserved Domains (1) summary
      pfam00348
      Location:33 → 297
      polyprenyl_synt; Polyprenyl synthetase

    2. NM_001341194.1 → NP_001328530.1  farnesyl diphosphate synthase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B4W4, A0A5S9XT96, A0A7G2F1F7

    3. NM_202836.2 → NP_974565.1  farnesyl diphosphate synthase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974565.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JNF1
      Conserved Domains (1) summary
      pfam00348
      Location:1 → 206
      polyprenyl_synt; Polyprenyl synthetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q43315.1

    Gene LinkOut

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