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    HOS1 ubiquitin-protein ligase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818568, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HOS1
    Official Full Name
    ubiquitin-protein ligase
    Primary source
    TAIR:AT2G39810
    Locus tag
    AT2G39810
    See related
    Araport:AT2G39810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    EARLY IN SHORT DAYS 6; ESD6; HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 1; T5I7.11; T5I7_11
    Summary
    A novel protein with a RING finger motif near the amino terminus. Negative regulator of cold responses. Functions as an E3 ligase required for the ubiquitination of ICE1. HOS1 physically interacts with ICE1 and mediates the ubiquitination of ICE1 both in vitro and in vivo. Overexpression represses the expression of CBFs and their downstream genes and confers increased sensitivity to freezing stress.
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    Genomic context

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    See HOS1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Sequence:
    Chromosome: 2; NC_003071.7 (16612777..16618122)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Mitochondrial glycoprotein family protein Neighboring gene delta1-pyrroline-5-carboxylate synthase 1 Neighboring gene Integral membrane Yip1 family protein Neighboring gene Translation initiation factor IF6 Neighboring gene DA1-related protein 2 Neighboring gene type one serine/threonine protein phosphatase 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HOS1 promotes plant tolerance to low-energy stress via the SnRK1 protein kinase. Margalha L, et al. Plant J, 2023 Aug. PMID 37077033
    2. The Arabidopsis HOS1 gene negatively regulates cold signal transduction and encodes a RING finger protein that displays cold-regulated nucleo--cytoplasmic partitioning. Lee H, et al. Genes Dev, 2001 Apr 1. PMID 11297514, Free PMC Article
    3. Molecular genetic analysis of cold-regulated gene transcription. Viswanathan C, et al. Philos Trans R Soc Lond B Biol Sci, 2002 Jul 29. PMID 12171651, Free PMC Article
    4. HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES1 is required for circadian periodicity through the promotion of nucleo-cytoplasmic mRNA export in Arabidopsis. MacGregor DR, et al. Plant Cell, 2013 Nov. PMID 24254125, Free PMC Article
    5. HOS1 acts as a key modulator of hypocotyl photomorphogenesis. Kim JH, et al. Plant Signal Behav, 2017 May 4. PMID 28426369, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The HOS1-PIF4/5 module controls callus formation in Arabidopsis leaf explants.
      Title: The HOS1-PIF4/5 module controls callus formation in Arabidopsis leaf explants.
    2. HOS1 promotes plant tolerance to low-energy stress via the SnRK1 protein kinase.
      Title: HOS1 promotes plant tolerance to low-energy stress via the SnRK1 protein kinase.
    3. Nucleoporin 160 Regulates Flowering through Anchoring HOS1 for Destabilizing CO in Arabidopsis.
      Title: Nucleoporin 160 Regulates Flowering through Anchoring HOS1 for Destabilizing CO in Arabidopsis.
    4. Nup96 and HOS1 Are Mutually Stabilized and Gate CONSTANS Protein Level, Conferring Long-Day Photoperiodic Flowering Regulation in Arabidopsis.
      Title: Nup96 and HOS1 Are Mutually Stabilized and Gate CONSTANS Protein Level, Conferring Long-Day Photoperiodic Flowering Regulation in Arabidopsis.
    5. While HOS1 is known to act as an E3 ubiquitin ligase or a chromatin remodeling factor, data illustrate a novel role of HOS1: it acts as a component of phyB-mediated light signaling in hypocotyl photomorphogenesis.
      Title: HOS1 acts as a key modulator of hypocotyl photomorphogenesis.
    6. HOS1 is intimately linked with hypocotyl growth, in which HOS1 inhibits the transcriptional activation activity of PIF4
      Title: HOS1 Facilitates the Phytochrome B-Mediated Inhibition of PIF4 Function during Hypocotyl Growth in Arabidopsis.
    7. Red light-mediated degradation of CO protein by HOS1 ligase regulates photoperiodic flowering in Arabidopsis.HOS1 and PHYB regulate flowering time additively.
      Title: Red Light-Mediated Degradation of CONSTANS by the E3 Ubiquitin Ligase HOS1 Regulates Photoperiodic Flowering in Arabidopsis.
    8. HOS1 regulates miR168a/b and AGO1 levels in Arabidopsis by maintaining proper transcription of MIR168b.
      Title: HOS1 regulates Argonaute1 by promoting transcription of the microRNA gene MIR168b in Arabidopsis.
    9. HOS1 regulates FLC transcription via chromatin remodeling.
      Title: HOS1-mediated activation of FLC via chromatin remodeling under cold stress.
    10. HOS1 is required for circadian periodicity through the promotion of nucleo-cytoplasmic mRNA export.
      Title: HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES1 is required for circadian periodicity through the promotion of nucleo-cytoplasmic mRNA export in Arabidopsis.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    NM_001336798.1
    NM_129540.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vegetative to reproductive phase transition of meristem IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vegetative to reproductive phase transition of meristem IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-protein ligase
    NP_181511.3
    • HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 1 (HOS1); FUNCTIONS IN: ubiquitin-protein ligase activity; INVOLVED IN: response to cold, negative regulation of transcription, protein ubiquitination; LOCATED IN: nucleus, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 12 growth stages; Has 239 Blast hits to 237 proteins in 68 species: Archae - 0; Bacteria - 0; Metazoa - 131; Fungi - 0; Plants - 80; Viruses - 5; Other Eukaryotes - 23 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      16612777..16618122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129540.5 → NP_181511.3  ubiquitin-protein ligase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181511.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22289, Q84JU6
      UniProtKB/TrEMBL
      A0A178W236, A0A5S9X5M0, A0A654F0D1
      Conserved Domains (2) summary
      pfam13934
      Location:323 → 596
      ELYS; Nuclear pore complex assembly
      cl17238
      Location:66 → 93
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. NM_001336798.1 → NP_001324757.1  ubiquitin-protein ligase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B159, A0A654F0D1, A0A7G2EFT6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84JU6.1

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