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    Acsl3 acyl-CoA synthetase long-chain family member 3 [ Mus musculus (house mouse) ]

    Gene ID: 74205, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acsl3provided by MGI
    Official Full Name
    acyl-CoA synthetase long-chain family member 3provided by MGI
    Primary source
    MGI:MGI:1921455
    See related
    Ensembl:ENSMUSG00000032883 AllianceGenome:MGI:1921455
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Acs3; Facl3; LACS 3; Pro2194; 2610510B12Rik
    Summary
    Predicted to enable arachidonate-CoA ligase activity; protein domain specific binding activity; and protein kinase binding activity. Predicted to be involved in several processes, including fatty acid metabolic process; positive regulation of phosphatidylcholine biosynthetic process; and positive regulation of transport. Predicted to be located in Golgi apparatus and perinuclear region of cytoplasm. Predicted to be active in endoplasmic reticulum; lipid droplet; and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in asthma; breast cancer; and prostate cancer. Orthologous to human ACSL3 (acyl-CoA synthetase long chain family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cortex adult (RPKM 21.5), frontal lobe adult (RPKM 18.3) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Acsl3 in Genome Data Viewer
    Location:
    1 C4; 1 40.84 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (78635600..78685462)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (78657825..78707743)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene monoacylglycerol O-acyltransferase 1 Neighboring gene predicted gene, 39665 Neighboring gene RIKEN cDNA 5730419F03 gene Neighboring gene STARR-seq mESC enhancer starr_01430 Neighboring gene STARR-seq mESC enhancer starr_01431 Neighboring gene predicted gene, 57683 Neighboring gene STARR-seq mESC enhancer starr_01433 Neighboring gene STARR-positive B cell enhancer ABC_E5775 Neighboring gene UTP14B small subunit processome component Neighboring gene predicted gene, 51635 Neighboring gene predicted gene, 38631 Neighboring gene predicted gene, 33693 Neighboring gene STARR-seq mESC enhancer starr_01434 Neighboring gene heterogeneous nuclear ribonucleoprotein R pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Restriction of extracellular lipids renders pancreatic cancer dependent on autophagy. Saliakoura M, et al. J Exp Clin Cancer Res, 2022 Jan 8. PMID 34998392, Free PMC Article
    2. Rab18 binds PLIN2 and ACSL3 to mediate lipid droplet dynamics. Deng Y, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2021 Jul. PMID 33713834
    3. Suppression of long chain acyl-CoA synthetase 3 decreases hepatic de novo fatty acid synthesis through decreased transcriptional activity. Bu SY, et al. J Biol Chem, 2009 Oct 30. PMID 19737935, Free PMC Article
    4. ACSL3-PAI-1 signaling axis mediates tumor-stroma cross-talk promoting pancreatic cancer progression. Rossi Sebastiano M, et al. Sci Adv, 2020 Oct. PMID 33127675, Free PMC Article
    5. Mouse very long-chain Acyl-CoA synthetase 3/fatty acid transport protein 3 catalyzes fatty acid activation but not fatty acid transport in MA-10 cells. Pei Z, et al. J Biol Chem, 2004 Dec 24. PMID 15469937

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ANKRD1 aggravates renal ischaemia-reperfusion injury via promoting TRIM25-mediated ubiquitination of ACSL3.
      Title: ANKRD1 aggravates renal ischaemia‒reperfusion injury via promoting TRIM25-mediated ubiquitination of ACSL3.
    2. ACSL3-PAI-1 signaling axis mediates tumor-stroma cross-talk promoting pancreatic cancer progression.
      Title: ACSL3-PAI-1 signaling axis mediates tumor-stroma cross-talk promoting pancreatic cancer progression.
    3. Rab18 binds PLIN2 and ACSL3 to mediate lipid droplet dynamics.
      Title: Rab18 binds PLIN2 and ACSL3 to mediate lipid droplet dynamics.
    4. The ACSL3-LPIAT1 signaling drives prostaglandin synthesis in non-small cell lung cancer.
      Title: The ACSL3-LPIAT1 signaling drives prostaglandin synthesis in non-small cell lung cancer.
    5. ACSL3 expression is up-regulated in ob/ob mice and mice fed a high sucrose diet
      Title: Suppression of long chain acyl-CoA synthetase 3 decreases hepatic de novo fatty acid synthesis through decreased transcriptional activity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Gene trapped (1) 
    • Targeted (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arachidonate-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonate-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables medium-chain fatty acid-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty acid import into cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of long-chain fatty acid import into cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in long-chain fatty-acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of Golgi to plasma membrane protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of Golgi to plasma membrane protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phosphatidylcholine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of phosphatidylcholine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in very-low-density lipoprotein particle assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in very-low-density lipoprotein particle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fatty acid CoA ligase Acsl3
    Names
    arachidonate--CoA ligase
    fatty acid Coenzyme A ligase, long chain 3
    long-chain acyl-CoA synthetase 3
    long-chain-fatty-acid--CoA ligase 3
    medium-chain acyl-CoA ligase Acsl3
    NP_001028778.2
    NP_001129694.1
    NP_001396004.1
    NP_001396005.1
    NP_001396006.1
    NP_001396007.1
    NP_001396008.1
    NP_083093.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033606.3 → NP_001028778.2  fatty acid CoA ligase Acsl3 isoform a

      See identical proteins and their annotated locations for NP_001028778.2

      Status: VALIDATED

      Source sequence(s)
      AC156613
      Consensus CDS
      CCDS15087.1
      UniProtKB/Swiss-Prot
      Q8K1J7, Q9CZW4
      Related
      ENSMUSP00000121695.2, ENSMUST00000142704.8
      Conserved Domains (1) summary
      PLN02387
      Location:30 → 717
      PLN02387; long-chain-fatty-acid-CoA ligase family protein

    2. NM_001136222.2 → NP_001129694.1  fatty acid CoA ligase Acsl3 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC156613
      Consensus CDS
      CCDS48295.1
      UniProtKB/TrEMBL
      E9PUC2
      Related
      ENSMUSP00000117952.2, ENSMUST00000134566.8
      Conserved Domains (1) summary
      cd05927
      Location:2 → 565
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    3. NM_001409075.1 → NP_001396004.1  fatty acid CoA ligase Acsl3 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC156613

    4. NM_001409076.1 → NP_001396005.1  fatty acid CoA ligase Acsl3 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC156613

    5. NM_001409077.1 → NP_001396006.1  fatty acid CoA ligase Acsl3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC156613
      UniProtKB/Swiss-Prot
      Q8K1J7, Q9CZW4

    6. NM_001409078.1 → NP_001396007.1  fatty acid CoA ligase Acsl3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC156613
      UniProtKB/Swiss-Prot
      Q8K1J7, Q9CZW4

    7. NM_001409079.1 → NP_001396008.1  fatty acid CoA ligase Acsl3 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC156613
      UniProtKB/TrEMBL
      E9PUC2

    8. NM_028817.4 → NP_083093.2  fatty acid CoA ligase Acsl3 isoform a

      See identical proteins and their annotated locations for NP_083093.2

      Status: VALIDATED

      Source sequence(s)
      AC156613
      Consensus CDS
      CCDS15087.1
      UniProtKB/Swiss-Prot
      Q8K1J7, Q9CZW4
      Related
      ENSMUSP00000045291.9, ENSMUST00000035779.15
      Conserved Domains (1) summary
      PLN02387
      Location:30 → 717
      PLN02387; long-chain-fatty-acid-CoA ligase family protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      78635600..78685462
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZW4.2 GenPept UniProtKB/Swiss-Prot:Q9CZW4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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