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    Dmac2l distal membrane arm assembly component 2 like [ Mus musculus (house mouse) ]

    Gene ID: 68055, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dmac2lprovided by MGI
    Official Full Name
    distal membrane arm assembly component 2 likeprovided by MGI
    Primary source
    MGI:MGI:1915305
    See related
    Ensembl:ENSMUSG00000054894 AllianceGenome:MGI:1915305
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ATPW; Atp5s; 1110015E18Rik
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in ATP biosynthetic process and proton transmembrane transport. Located in mitochondrion. Is expressed in several structures, including brain; gallbladder; genitourinary system; gut; and respiratory system. Orthologous to human DMAC2L (distal membrane arm assembly component 2 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 6.3), bladder adult (RPKM 3.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dmac2l in Genome Data Viewer
    Location:
    12 C2; 12 28.94 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (69771687..69791439)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (69724913..69744665)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene SOS Ras/Rho guanine nucleotide exchange factor 2 Neighboring gene chloride intracellular channel protein 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_32374 Neighboring gene L-2-hydroxyglutarate dehydrogenase Neighboring gene STARR-positive B cell enhancer ABC_E2387 Neighboring gene STARR-positive B cell enhancer mm9_chr12:70834549-70834850 Neighboring gene VISTA enhancer mm122 Neighboring gene cyclin dependent kinase like 1 Neighboring gene RIKEN cDNA 4930512B01 gene Neighboring gene microRNA 681 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 5 Neighboring gene ribosomal protein S2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Evidence for the involvement of coupling factor B in the H+ channel of the mitochondrial H+-ATPase. Sanadi DR, et al. Proc Natl Acad Sci U S A, 1984 Mar. PMID 6143319, Free PMC Article
    2. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase subunit s, mitochondrial
    Names
    ATP synthase, H+ transporting, mitochondrial F0 complex, subunit S
    ATP synthase-coupling factor B
    distal membrane arm assembly complex 2 like
    distal membrane arm assembly complex 2-like protein
    mitochondrial ATP synthase regulatory component factor B
    NP_001348619.1
    NP_001348620.1
    NP_080812.1
    XP_006516243.1
    XP_006516244.1
    XP_011242464.1
    XP_011242465.1
    XP_011242466.1
    XP_030102747.1
    XP_030102748.1
    XP_030102749.1
    XP_036013491.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361690.1 → NP_001348619.1  ATP synthase subunit s, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      AI844080, AK003725, AK009141, BB869492
      Consensus CDS
      CCDS25954.1
      UniProtKB/Swiss-Prot
      Q8R2M3, Q9CRA7
      Related
      ENSMUSP00000152430.2, ENSMUST00000220916.2
      Conserved Domains (2) summary
      cd09293
      Location:97 → 166
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:111 → 139
      LRR_AMN1; leucine-rich repeat [structural motif]

    2. NM_001361691.1 → NP_001348620.1  ATP synthase subunit s, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      AC141560
      Consensus CDS
      CCDS25954.1
      UniProtKB/Swiss-Prot
      Q8R2M3, Q9CRA7
      Conserved Domains (2) summary
      cd09293
      Location:97 → 166
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:111 → 139
      LRR_AMN1; leucine-rich repeat [structural motif]

    3. NM_026536.2 → NP_080812.1  ATP synthase subunit s, mitochondrial precursor

      See identical proteins and their annotated locations for NP_080812.1

      Status: VALIDATED

      Source sequence(s)
      AI844080, AK003725, BB869492
      Consensus CDS
      CCDS25954.1
      UniProtKB/Swiss-Prot
      Q8R2M3, Q9CRA7
      Related
      ENSMUSP00000021372.6, ENSMUST00000021372.6
      Conserved Domains (2) summary
      cd09293
      Location:97 → 166
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:111 → 139
      LRR_AMN1; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      69771687..69791439
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516180.4 → XP_006516243.1  ATP synthase subunit s, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006516243.1

      Conserved Domains (1) summary
      cd09293
      Location:97 → 159
      AMN1; Antagonist of mitotic exit network protein 1

    2. XM_011244162.3 → XP_011242464.1  ATP synthase subunit s, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_011242464.1

      Conserved Domains (1) summary
      cd09293
      Location:97 → 159
      AMN1; Antagonist of mitotic exit network protein 1

    3. XM_030246887.2 → XP_030102747.1  ATP synthase subunit s, mitochondrial isoform X1

      Conserved Domains (1) summary
      cd09293
      Location:97 → 159
      AMN1; Antagonist of mitotic exit network protein 1

    4. XM_030246888.2 → XP_030102748.1  ATP synthase subunit s, mitochondrial isoform X2

      UniProtKB/Swiss-Prot
      Q8R2M3, Q9CRA7
      Conserved Domains (2) summary
      cd09293
      Location:97 → 166
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:111 → 139
      LRR_AMN1; leucine-rich repeat [structural motif]

    5. XM_006516181.4 → XP_006516244.1  ATP synthase subunit s, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006516244.1

      Conserved Domains (1) summary
      cd09293
      Location:97 → 159
      AMN1; Antagonist of mitotic exit network protein 1

    6. XM_036157598.1 → XP_036013491.1  ATP synthase subunit s, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A1Y7VK84
      Related
      ENSMUSP00000152757.2, ENSMUST00000220460.2
      Conserved Domains (1) summary
      cd09293
      Location:97 → 159
      AMN1; Antagonist of mitotic exit network protein 1

    7. XM_011244164.4 → XP_011242466.1  ATP synthase subunit s, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_011242466.1

      Conserved Domains (1) summary
      cd09293
      Location:97 → 159
      AMN1; Antagonist of mitotic exit network protein 1

    8. XM_011244163.4 → XP_011242465.1  ATP synthase subunit s, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_011242465.1

      Conserved Domains (1) summary
      cd09293
      Location:97 → 159
      AMN1; Antagonist of mitotic exit network protein 1

    9. XM_030246889.2 → XP_030102749.1  ATP synthase subunit s, mitochondrial isoform X2

      UniProtKB/Swiss-Prot
      Q8R2M3, Q9CRA7
      Conserved Domains (2) summary
      cd09293
      Location:97 → 166
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:111 → 139
      LRR_AMN1; leucine-rich repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CRA7.1 GenPept UniProtKB/Swiss-Prot:Q9CRA7

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