Il7 interleukin 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il7provided by MGI
Official Full Name: interleukin 7provided by MGI
Primary source: MGI:MGI:96561
See related: Ensembl:ENSMUSG00000040329 AllianceGenome:MGI:96561
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Il-7; hlb368; A630026I06Rik
Summary: The protein encoded by this gene is a hematopoietic growth factor important for B and T cell development. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Expression: Broad expression in thymus adult (RPKM 2.5), spleen adult (RPKM 1.2) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 A1; 3 2.02 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (7637088..7678820, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (7572028..7613760, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-7 Deficiency Exacerbates Atopic Dermatitis in NC/Nga Mice.
Title: IL-7 Deficiency Exacerbates Atopic Dermatitis in NC/Nga Mice.
Interleukin-7 aggravates myocardial ischaemia/reperfusion injury by regulating macrophage infiltration and polarization.
Title: Interleukin-7 aggravates myocardial ischaemia/reperfusion injury by regulating macrophage infiltration and polarization.
The Broad Immunomodulatory Effects of IL-7 and Its Application In Vaccines.
Title: The Broad Immunomodulatory Effects of IL-7 and Its Application In Vaccines.
Selective dependence on IL-7 for antigen-specific CD8 T cell responses during airway influenza infection.
Title: Selective dependence on IL-7 for antigen-specific CD8 T cell responses during airway influenza infection.
In vivo availability of the cytokine IL-7 constrains the survival and homeostasis of peripheral iNKT cells.
Title: In vivo availability of the cytokine IL-7 constrains the survival and homeostasis of peripheral iNKT cells.
Interleukin-7 protects CD8(+) T cells from adenosine-mediated immunosuppression.
Title: Interleukin-7 protects CD8(+) T cells from adenosine-mediated immunosuppression.
Prosurvival IL-7-Stimulated Weak Strength of mTORC1-S6K Controls T Cell Memory via Transcriptional FOXO1-TCF1-Id3 and Metabolic AMPKalpha1-ULK1-ATG7 Pathways.
Title: Prosurvival IL-7-Stimulated Weak Strength of mTORC1-S6K Controls T Cell Memory via Transcriptional FOXO1-TCF1-Id3 and Metabolic AMPKα1-ULK1-ATG7 Pathways.
IL-2/IL-7-inducible factors pioneer the path to T cell differentiation in advance of lineage-defining factors.
Title: IL-2/IL-7-inducible factors pioneer the path to T cell differentiation in advance of lineage-defining factors.
Interleukin-7 protects against bacterial respiratory infection by promoting IL-17A-producing innate T-cell response.
Title: Interleukin-7 protects against bacterial respiratory infection by promoting IL-17A-producing innate T-cell response.
IL-7 derived from lymph node fibroblastic reticular cells is dispensable for naive T cell homeostasis but crucial for central memory T cell survival.
Title: IL-7 derived from lymph node fibroblastic reticular cells is dispensable for naive T cell homeostasis but crucial for central memory T cell survival.

Submit: New GeneRIF Correction See all GeneRIFs (182)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (5)
Targeted (11) 1 citation

General gene information

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Markers

Il7 (e-PCR), detects polymorphism
- UniSTS:526085

Il7 (e-PCR), detects polymorphism
- UniSTS:261907

X07962 (e-PCR)
- UniSTS:125795

NoName (e-PCR)
- UniSTS:234640

Il7 (e-PCR), detects polymorphism
- UniSTS:502727

Il7 (e-PCR), detects polymorphism
- UniSTS:143580

Il7 (e-PCR), detects polymorphism
- UniSTS:143581

Il7 (e-PCR), detects polymorphism
- UniSTS:143582

X07962 (e-PCR)
- UniSTS:163308

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IDA Inferred from Direct Assay more info	PubMed
enables interleukin-7 receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of B cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within T cell lineage commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone resorption	IDA Inferred from Direct Assay more info	PubMed
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of extrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within homeostasis of number of cells within a tissue	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-7-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-7-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of catalytic activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of organ growth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of B cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of B cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of B cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of T cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of chemokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of organ growth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001313888.1 → NP_001300817.1 interleukin-7 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate exon near the 5' end compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (b) with a shorter N-terminus, compared to isoform a.

Source sequence(s)

AK040399, AK052452

Consensus CDS

CCDS84608.1

UniProtKB/TrEMBL

Q3UT18, Q8C9S3

Related

ENSMUSP00000141508.2, ENSMUST00000192202.6

Conserved Domains (1) summary

cl11602
Location:1 → 111

IL7; Interleukin 7/9 family
NM_001313889.1 → NP_001300818.1 interleukin-7 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate exon near the 5' end and an alternate internal exon compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (c) with a shorter N-terminus, compared to isoform a.

Source sequence(s)

AK040399, AK042009, AK052452

Conserved Domains (1) summary

cl11602
Location:1 → 102

IL7; Interleukin 7/9 family
NM_001313890.1 → NP_001300819.1 interleukin-7 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains two alternate exons in place of the first exon compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (b) with a shorter N-terminus, compared to isoform a. Variants 2 and 4 both encode the same isoform (b).

Source sequence(s)

AK040399, AK139858

Consensus CDS

CCDS84608.1

UniProtKB/TrEMBL

Q3UT18, Q8C9S3

Related

ENSMUSP00000141827.2, ENSMUST00000194184.6

Conserved Domains (1) summary

cl11602
Location:1 → 111

IL7; Interleukin 7/9 family
NM_008371.5 → NP_032397.1 interleukin-7 isoform a precursor

See identical proteins and their annotated locations for NP_032397.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

AK040399, AK041307, AK052452

Consensus CDS

CCDS50859.1

UniProtKB/Swiss-Prot

P10168

UniProtKB/TrEMBL

Q544C8, Q8C9S3

Related

ENSMUSP00000141845.2, ENSMUST00000194279.6

Conserved Domains (1) summary

smart00127
Location:27 → 152

IL7; Interleukin-7 and interleukin-9 family