Cwf19l2 CWF19 like cell cycle control factor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cwf19l2provided by MGI
Official Full Name: CWF19 like cell cycle control factor 2provided by MGI
Primary source: MGI:MGI:1918023
See related: Ensembl:ENSMUSG00000025898 AllianceGenome:MGI:1918023
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9030209E10; 3230401L03Rik
Summary: Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of post-mRNA release spliceosomal complex. Orthologous to human CWF19L2 (CWF19 like cell cycle control factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E11.5 (RPKM 2.3), bladder adult (RPKM 2.1) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A1; 9 2.06 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (3403592..3479236)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (3403592..3479236)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CWF19L2 is Essential for Male Fertility and Spermatogenesis by Regulating Alternative Splicing.
Title: CWF19L2 is Essential for Male Fertility and Spermatogenesis by Regulating Alternative Splicing.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of post-mRNA release spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CWF19-like protein 2

Names: CWF19-like 2, cell cycle control

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027545.2 → NP_081821.1 CWF19-like protein 2

See identical proteins and their annotated locations for NP_081821.1

Status: PROVISIONAL

Source sequence(s)

AK045423

Consensus CDS

CCDS22793.1

UniProtKB/Swiss-Prot

Q3TIS8, Q3UX04, Q80XN7, Q8BG79, Q8BZV5, Q8C0F8

Related

ENSMUSP00000027027.6, ENSMUST00000027027.7

Conserved Domains (2) summary

pfam04676
Location:788 → 882

CwfJ_C_2; Protein similar to CwfJ C-terminus 2

cl00228
Location:655 → 779

HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

3403592..3479236

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509865.2 → XP_006509928.1 CWF19-like protein 2 isoform X1

Conserved Domains (1) summary

cl00228
Location:655 → 779

HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...