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    Anks4b ankyrin repeat and sterile alpha motif domain containing 4B [ Mus musculus (house mouse) ]

    Gene ID: 72074, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Anks4bprovided by MGI
    Official Full Name
    ankyrin repeat and sterile alpha motif domain containing 4Bprovided by MGI
    Primary source
    MGI:MGI:1919324
    See related
    Ensembl:ENSMUSG00000030909 AllianceGenome:MGI:1919324
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Harp; 2010013E14Rik
    Summary
    Acts upstream of or within response to endoplasmic reticulum stress. Located in several cellular components, including brush border; endoplasmic reticulum membrane; and microvillus. Is expressed in alimentary system; cochlea epithelium; genitourinary system; liver; and lung epithelium. Orthologous to human ANKS4B (ankyrin repeat and sterile alpha motif domain containing 4B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in large intestine adult (RPKM 15.4), liver adult (RPKM 8.9) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Anks4b in Genome Data Viewer
    Location:
    7 F2; 7 64.45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (119773081..119782939)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (120173858..120183716)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zona pellucida glycoprotein 2 Neighboring gene RIKEN cDNA 4930505K13 gene Neighboring gene STARR-seq mESC enhancer starr_20043 Neighboring gene crystallin, mu Neighboring gene ATP-binding cassette, sub-family A member 14 Neighboring gene STARR-seq mESC enhancer starr_20044 Neighboring gene STARR-seq mESC enhancer starr_20045 Neighboring gene STARR-seq mESC enhancer starr_20046

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ANKS4B Is Essential for Intermicrovillar Adhesion Complex Formation. Crawley SW, et al. Dev Cell, 2016 Jan 25. PMID 26812018, Free PMC Article
    2. Harp (harmonin-interacting, ankyrin repeat-containing protein), a novel protein that interacts with harmonin in epithelial tissues. Johnston AM, et al. Genes Cells, 2004 Oct. PMID 15461667
    3. Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells. Sato Y, et al. J Biol Chem, 2012 Jun 29. PMID 22589549, Free PMC Article
    4. Agouti C57BL/6N embryonic stem cells for mouse genetic resources. Pettitt SJ, et al. Nat Methods, 2009 Jul. PMID 19525957, Free PMC Article
    5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Anks4b is a HNF4alpha target gene that regulates endoplasmic reticulum stress in beta-cells by interacting with GRP78, thus suggesting that HNF4alpha is involved in maintenance of the ER.
      Title: Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells.
    2. Harp + harmonin constitute a scaffolding complex to facilitate signal transduction in epithelia.
      Title: Harp (harmonin-interacting, ankyrin repeat-containing protein), a novel protein that interacts with harmonin in epithelial tissues.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144693, MGC144694

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in brush border assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in brush border assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in brush border assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to microvillus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to microvillus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microvillus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microvillus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ankyrin repeat and SAM domain-containing protein 4B
    Names
    harmonin-interacting ankyrin repeat-containing protein
    harmonin-interacting ankyrin-repeat containing

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028085.2 → NP_082361.2  ankyrin repeat and SAM domain-containing protein 4B

      See identical proteins and their annotated locations for NP_082361.2

      Status: VALIDATED

      Source sequence(s)
      AI956809, AK008229, BC118013, BY106969
      Consensus CDS
      CCDS21793.1
      UniProtKB/Swiss-Prot
      Q148R3, Q8K3X6, Q9D8A5
      Related
      ENSMUSP00000033201.6, ENSMUST00000033201.7
      Conserved Domains (5) summary
      cd09587
      Location:350 → 416
      SAM_HARP; SAM domain of HARP subfamily
      smart00454
      Location:357 → 410
      SAM; Sterile alpha motif
      cd00204
      Location:3 → 117
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:6 → 95
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:3 → 29
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      119773081..119782939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K3X6.1 GenPept UniProtKB/Swiss-Prot:Q8K3X6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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