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    Mob1a MOB kinase activator 1A [ Mus musculus (house mouse) ]

    Gene ID: 232157, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mob1aprovided by MGI
    Official Full Name
    MOB kinase activator 1Aprovided by MGI
    Primary source
    MGI:MGI:2442631
    See related
    Ensembl:ENSMUSG00000043131 AllianceGenome:MGI:2442631
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MOB1; MOB4B; Mobk1b; Mobkl1b; 4022402H07Rik
    Summary
    Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in hippo signaling. Predicted to be active in cytoplasm and nucleus. Is expressed in hippocampus; lung; and spinal cord. Orthologous to human MOB1A (MOB kinase activator 1A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 24.7), bladder adult (RPKM 21.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mob1a in Genome Data Viewer
    Location:
    6 C3; 6 35.94 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (83303016..83320758)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (83326034..83342812)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 4, sodium bicarbonate cotransporter, member 5 Neighboring gene STARR-seq mESC enhancer starr_16459 Neighboring gene STARR-positive B cell enhancer ABC_E4836 Neighboring gene STARR-positive B cell enhancer ABC_E1323 Neighboring gene STARR-positive B cell enhancer ABC_E6448 Neighboring gene methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase Neighboring gene STARR-seq mESC enhancer starr_16463 Neighboring gene bolA family member 3 Neighboring gene tet methylcytosine dioxygenase 3 Neighboring gene microRNA 6374

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MOB1 regulates thymocyte egress and T-cell survival in mice in a YAP1-independent manner. Kato W, et al. Genes Cells, 2019 Jul. PMID 31125466
    2. Hippo pathway controls cell adhesion and context-dependent cell competition to influence skin engraftment efficiency. Nishio M, et al. FASEB J, 2019 Apr. PMID 30640535
    3. The Legionella kinase LegK7 exploits the Hippo pathway scaffold protein MOB1A for allostery and substrate phosphorylation. Lee PC, et al. Proc Natl Acad Sci U S A, 2020 Jun 23. PMID 32513747, Free PMC Article
    4. Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice. Nishio M, et al. J Clin Invest, 2012 Dec. PMID 23143302, Free PMC Article
    5. EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1. Ando T, et al. Commun Biol, 2021 Nov 1. PMID 34725466, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1.
      Title: EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1.
    2. The Legionella kinase LegK7 exploits the Hippo pathway scaffold protein MOB1A for allostery and substrate phosphorylation.
      Title: The Legionella kinase LegK7 exploits the Hippo pathway scaffold protein MOB1A for allostery and substrate phosphorylation.
    3. MOB1A/B has an essential function for intestinal epithelial homeostasis.
      Title: Depletion of MOB1A/B causes intestinal epithelial degeneration by suppressing Wnt activity and activating BMP/TGF-β signaling.
    4. T-cell-specific double knockout of MOB1A/B in mice reduces the number of naive T cells in both the circulation and secondary lymphoid organs, but leads to an accumulation of CD4(+) CD8(-) and CD4(-) CD8(+) single-positive cells in the thymus.
      Title: MOB1 regulates thymocyte egress and T-cell survival in mice in a YAP1-independent manner.
    5. MOB1A and MOB1B have overlapping functions in skin homeostasis, and exert their roles as tumor suppressors by regulating downstream elements of the Hippo pathway.
      Title: Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC6884

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hippo signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hippo signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MOB kinase activator 1A
    Names
    MOB1, Mps One Binder kinase activator-like 1B
    mob1 homolog 1B
    mps one binder kinase activator-like 1B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418174.1 → NP_001405103.1  MOB kinase activator 1A isoform b

      Status: VALIDATED

      Source sequence(s)
      AC159713

    2. NM_001418175.1 → NP_001405104.1  MOB kinase activator 1A isoform b

      Status: VALIDATED

      Source sequence(s)
      AC159713

    3. NM_001418176.1 → NP_001405105.1  MOB kinase activator 1A isoform b

      Status: VALIDATED

      Source sequence(s)
      AC159713

    4. NM_001418177.1 → NP_001405106.1  MOB kinase activator 1A isoform b

      Status: VALIDATED

      Source sequence(s)
      AC159713

    5. NM_001418178.1 → NP_001405107.1  MOB kinase activator 1A isoform c

      Status: VALIDATED

      Source sequence(s)
      AC159713
      Related
      ENSMUSP00000039115.9, ENSMUST00000038658.15

    6. NM_001418179.1 → NP_001405108.1  MOB kinase activator 1A isoform d

      Status: VALIDATED

      Source sequence(s)
      AC159713

    7. NM_145571.3 → NP_663546.1  MOB kinase activator 1A isoform a

      See identical proteins and their annotated locations for NP_663546.1

      Status: VALIDATED

      Source sequence(s)
      AC159713
      Consensus CDS
      CCDS39533.1
      UniProtKB/Swiss-Prot
      Q3TJA6, Q8C194, Q8C1C7, Q921Y0
      UniProtKB/TrEMBL
      Q3UDM0
      Related
      ENSMUSP00000054452.5, ENSMUST00000055261.11
      Conserved Domains (1) summary
      pfam03637
      Location:33 → 204
      Mob1_phocein; Mob1/phocein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      83303016..83320758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505969.4 → XP_006506032.1  MOB kinase activator 1A isoform X1

      See identical proteins and their annotated locations for XP_006506032.1

      UniProtKB/TrEMBL
      Q3UDM0
      Conserved Domains (1) summary
      pfam03637
      Location:32 → 203
      Mob1_phocein; Mob1/phocein family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q921Y0.3 GenPept UniProtKB/Swiss-Prot:Q921Y0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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