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    Cdkn1c cyclin dependent kinase inhibitor 1C [ Mus musculus (house mouse) ]

    Gene ID: 12577, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdkn1cprovided by MGI
    Official Full Name
    cyclin dependent kinase inhibitor 1Cprovided by MGI
    Primary source
    MGI:MGI:104564
    See related
    Ensembl:ENSMUSG00000037664 AllianceGenome:MGI:104564
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CDKI; Kip2; p57Kip2; p57(kip2)
    Summary
    Predicted to enable protein kinase inhibitor activity. Involved in negative regulation of phosphorylation. Acts upstream of or within several processes, including embryonic placenta morphogenesis; regulation of gene expression; and uterus development. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and sensory organ. Used to study Beckwith-Wiedemann syndrome and pre-eclampsia. Human ortholog(s) of this gene implicated in Beckwith-Wiedemann syndrome; IMAGe syndrome; and hyperinsulinism. Orthologous to human CDKN1C (cyclin dependent kinase inhibitor 1C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 280.3), adrenal adult (RPKM 244.3) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdkn1c in Genome Data Viewer
    Location:
    7 F5; 7 88.22 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (143012076..143014735, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143458339..143461059, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, subfamily Q, member 1 Neighboring gene KCNQ1 overlapping transcript 1 Neighboring gene STARR-positive B cell enhancer ABC_E10485 Neighboring gene RIKEN cDNA 4933417O13 gene Neighboring gene STARR-seq mESC enhancer starr_20528 Neighboring gene STARR-seq mESC enhancer starr_20529 Neighboring gene STARR-seq mESC enhancer starr_20530 Neighboring gene predicted gene, 33663 Neighboring gene solute carrier family 22 (organic cation transporter), member 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A human p57(KIP2) transgene is not activated by passage through the maternal mouse germline. John RM, et al. Hum Mol Genet, 1999 Nov. PMID 10545601
    2. Mice lacking a CDK inhibitor, p57Kip2, exhibit skeletal abnormalities and growth retardation. Takahashi K, et al. J Biochem, 2000 Jan. PMID 10731669
    3. p57Kip2 is expressed in quiescent mouse bone marrow side population cells. Umemoto T, et al. Biochem Biophys Res Commun, 2005 Nov 11. PMID 16176803
    4. p57 controls adult neural stem cell quiescence and modulates the pace of lifelong neurogenesis. Furutachi S, et al. EMBO J, 2013 Apr 3. PMID 23481253, Free PMC Article
    5. p57KIP2 targeted disruption and Beckwith-Wiedemann syndrome: is the inhibitor just a contributor? Swanger WJ, et al. Bioessays, 1997 Oct. PMID 9363677

    See all (422) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Protein restriction during pregnancy alters Cdkn1c silencing, dopamine circuitry and offspring behaviour without changing expression of key neuronal marker genes.
      Title: Protein restriction during pregnancy alters Cdkn1c silencing, dopamine circuitry and offspring behaviour without changing expression of key neuronal marker genes.
    2. Epigenetic control of the imprinted growth regulator Cdkn1c in cadmium-induced placental dysfunction.
      Title: Epigenetic control of the imprinted growth regulator Cdkn1c in cadmium-induced placental dysfunction.
    3. p57[Kip2] acts as a transcriptional corepressor to regulate intestinal stem cell fate and proliferation.
      Title: p57(Kip2) acts as a transcriptional corepressor to regulate intestinal stem cell fate and proliferation.
    4. p57Kip2 is an essential regulator of vitamin D receptor-dependent mechanisms.
      Title: p57Kip2 is an essential regulator of vitamin D receptor-dependent mechanisms.
    5. IGF2 interacts with the imprinted gene Cdkn1c to promote terminal differentiation of neural stem cells.
      Title: IGF2 interacts with the imprinted gene Cdkn1c to promote terminal differentiation of neural stem cells.
    6. p57(Kip2) imposes the reserve stem cell state of gastric chief cells.
      Title: p57(Kip2) imposes the reserve stem cell state of gastric chief cells.
    7. Role of the imprinted allele of the Cdkn1c gene in mouse neocortical development.
      Title: Role of the imprinted allele of the Cdkn1c gene in mouse neocortical development.
    8. Cdkn1c locus regulates cortical development through distinct cell-autonomous and non-cell-autonomous mechanisms.
      Title: Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development.
    9. The results reveal a novel Shh-Foxd1-Cdkn1c regulatory circuit that drives the mitogenic action of Shh signaling. Shh pathway activation of Foxd1 is followed by downregulation of Cdkn1c, which encodes a cyclin-dependent kinase inhibitor.
      Title: Coordinated d-cyclin/Foxd1 activation drives mitogenic activity of the Sonic Hedgehog signaling pathway.
    10. Here we show that loss of Ezh2 resulted in altered expression of several key cyclin-dependent kinase inhibitors including Cdkn2a (p16 and Arf) and Cdkn1c (p57) in naive CD8+ T cells after activation, which explained the cell cycle impairment of Ezh2-deficient naive CD8+ T cells in response to antigenic stimulation.
      Title: Ezh2 Regulates Activation-Induced CD8(+) T Cell Cycle Progression via Repressing Cdkn2a and Cdkn1c Expression.
    Submit: New GeneRIF Correction See all GeneRIFs (66)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular function inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adrenal gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within digestive system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic placenta morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within genomic imprinting IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within myeloid cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cyclin-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of epithelial cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within placenta development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within placenta development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of exit from mitosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of lens fiber cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within uterus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase inhibitor 1C
    Names
    cyclin dependent kinase inhibitor 1C (P57)
    cyclin-dependent kinase inhibitor p57

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161624.2 → NP_001155096.1  cyclin-dependent kinase inhibitor 1C isoform 1

      See identical proteins and their annotated locations for NP_001155096.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC023248
      Consensus CDS
      CCDS52463.1
      UniProtKB/Swiss-Prot
      G3UW61, P49919
      UniProtKB/TrEMBL
      Q8BP34
      Related
      ENSMUSP00000128828.2, ENSMUST00000167912.9
      Conserved Domains (2) summary
      PTZ00341
      Location:197 → 281
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      pfam02234
      Location:34 → 81
      CDI; Cyclin-dependent kinase inhibitor

    2. NM_001354981.2 → NP_001341910.1  cyclin-dependent kinase inhibitor 1C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC023248
      Consensus CDS
      CCDS22040.1
      UniProtKB/TrEMBL
      Q791X1, Q8BP34, Q91V06
      Conserved Domains (2) summary
      PTZ00341
      Location:184 → 268
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      pfam02234
      Location:21 → 68
      CDI; Cyclin-dependent kinase inhibitor

    3. NM_001412230.1 → NP_001399159.1  cyclin-dependent kinase inhibitor 1C isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC023248
      UniProtKB/TrEMBL
      Q8BP34

    4. NM_001412231.1 → NP_001399160.1  cyclin-dependent kinase inhibitor 1C isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC023248
      UniProtKB/TrEMBL
      Q8BP34

    5. NM_001412232.1 → NP_001399161.1  cyclin-dependent kinase inhibitor 1C isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC023248
      UniProtKB/Swiss-Prot
      G3UW61, P49919
      UniProtKB/TrEMBL
      Q8BP34

    6. NM_001412233.1 → NP_001399162.1  cyclin-dependent kinase inhibitor 1C isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC023248
      UniProtKB/TrEMBL
      Q8BP34

    7. NM_001412234.1 → NP_001399163.1  cyclin-dependent kinase inhibitor 1C isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC023248
      UniProtKB/TrEMBL
      Q8BP34

    8. NM_001412235.1 → NP_001399164.1  cyclin-dependent kinase inhibitor 1C isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC023248
      UniProtKB/TrEMBL
      Q8BP34

    9. NM_001412236.1 → NP_001399165.1  cyclin-dependent kinase inhibitor 1C isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC023248
      UniProtKB/TrEMBL
      Q8BP34

    10. NM_001412237.1 → NP_001399166.1  cyclin-dependent kinase inhibitor 1C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC023248
      UniProtKB/TrEMBL
      Q791X1, Q8BP34, Q91V06

    11. NM_001412238.1 → NP_001399167.1  cyclin-dependent kinase inhibitor 1C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC023248
      UniProtKB/TrEMBL
      Q791X1, Q8BP34, Q91V06

    12. NM_001412239.1 → NP_001399168.1  cyclin-dependent kinase inhibitor 1C isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC023248
      UniProtKB/TrEMBL
      Q8BP34

    13. NM_001412240.1 → NP_001399169.1  cyclin-dependent kinase inhibitor 1C isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC023248
      UniProtKB/TrEMBL
      Q8BP34

    14. NM_001412241.1 → NP_001399170.1  cyclin-dependent kinase inhibitor 1C isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC023248
      UniProtKB/TrEMBL
      Q8BP34

    15. NM_001412242.1 → NP_001399171.1  cyclin-dependent kinase inhibitor 1C isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC023248
      UniProtKB/TrEMBL
      Q8BP34

    16. NM_001412243.1 → NP_001399172.1  cyclin-dependent kinase inhibitor 1C isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC023248
      UniProtKB/TrEMBL
      Q8BP34

    17. NM_001412244.1 → NP_001399173.1  cyclin-dependent kinase inhibitor 1C isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC023248
      UniProtKB/TrEMBL
      Q8BP34

    18. NM_001412245.1 → NP_001399174.1  cyclin-dependent kinase inhibitor 1C isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC023248
      UniProtKB/TrEMBL
      Q8BP34

    19. NM_001412246.1 → NP_001399175.1  cyclin-dependent kinase inhibitor 1C isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC023248
      UniProtKB/TrEMBL
      Q8BP34

    20. NM_009876.5 → NP_034006.3  cyclin-dependent kinase inhibitor 1C isoform 2

      See identical proteins and their annotated locations for NP_034006.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate in-frame splice site in the 5' coding region and uses a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AC023248
      Consensus CDS
      CCDS22040.1
      UniProtKB/TrEMBL
      Q791X1, Q8BP34, Q91V06
      Related
      ENSMUSP00000037302.7, ENSMUST00000037287.8
      Conserved Domains (2) summary
      PTZ00341
      Location:184 → 268
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      pfam02234
      Location:21 → 68
      CDI; Cyclin-dependent kinase inhibitor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      143012076..143014735 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49919.2 GenPept UniProtKB/Swiss-Prot:P49919

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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