Serpinf2 serine (or cysteine) peptidase inhibitor, clade F, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Serpinf2provided by MGI
Official Full Name: serine (or cysteine) peptidase inhibitor, clade F, member 2provided by MGI
Primary source: MGI:MGI:107173
See related: Ensembl:ENSMUSG00000038224 AllianceGenome:MGI:107173
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pli; Serpimf2
Summary: Predicted to enable protease binding activity; protein homodimerization activity; and serine-type endopeptidase inhibitor activity. Involved in several processes, including collagen fibril organization; maintenance of blood vessel diameter homeostasis by renin-angiotensin; and positive regulation of biosynthetic process. Located in collagen-containing extracellular matrix. Is expressed in several structures, including liver; pancreas epithelium; urinary system; and yolk sac. Used to study alpha-2-plasmin inhibitor deficiency. Human ortholog(s) of this gene implicated in COVID-19 and alpha-2-plasmin inhibitor deficiency. Orthologous to human SERPINF2 (serpin family F member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver adult (RPKM 505.8), liver E18 (RPKM 427.0) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 45.89 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (75322562..75330327, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (75431736..75439501, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

alpha2-Antiplasmin is associated with macrophage activation and fibrin deposition in a macrophage activation syndrome mouse model.
Title: α2-Antiplasmin is associated with macrophage activation and fibrin deposition in a macrophage activation syndrome mouse model.
Alpha2-antiplasmin deficiency affects depression and anxiety-like behavior and apoptosis induced by stress in mice.
Title: Alpha2-antiplasmin deficiency affects depression and anxiety-like behavior and apoptosis induced by stress in mice.
alpha2-antiplasmin positively regulates endothelial-to-mesenchymal transition and fibrosis progression in diabetic nephropathy.
Title: α2-antiplasmin positively regulates endothelial-to-mesenchymal transition and fibrosis progression in diabetic nephropathy.
alpha2-Antiplasmin as a potential regulator of the spatial memory process and age-related cognitive decline.
Title: α2-Antiplasmin as a potential regulator of the spatial memory process and age-related cognitive decline.
Suppression of fibrinolysis by alpha2AP appears essential for stasis-induced thrombus development, which suggests that targeting alpha2AP may prove useful for preventing venous thrombosis.
Title: Venous stasis-induced fibrinolysis prevents thrombosis in mice: role of α2-antiplasmin.
These results suggest that alpha2AP negatively affects osteoblast differentiation and function by inhibiting the Wnt/beta-catenin pathway.
Title: α2-antiplasmin modulates bone formation by negatively regulating osteoblast differentiation and function.
alpha2AP has a profibrotic effect probably not by the action as a plasmin inhibitor, and the blocking of alpha2AP exerts an antifibrotic effect in humans and mice with systemic sclerosis
Title: The Antifibrotic Effect of α2AP Neutralization in Systemic Sclerosis Dermal Fibroblasts and Mouse Models of Systemic Sclerosis.
A2AP is not significantly affected by the Pla protease during pneumonic plague, and although A2AP participates in immune modulation in the lungs, it has limited impact on the course or ultimate outcome of the infection.
Title: Impact of the Pla protease substrate α2-antiplasmin on the progression of primary pneumonic plague.
a2AP deficiency enhanced thrombus dissolution, increased cerebral blood flow, reduced brain infarction, and decreased brain swelling.
Title: Microvascular thrombosis, fibrinolysis, ischemic injury, and death after cerebral thromboembolism are affected by levels of circulating α2-antiplasmin.
our findings suggest that alpha2AP is a crucial mediator of motor function, cognitive function, anxiety-like behavior and depression-like behavior, providing new insights into the role of alpha2AP in the brain functions.
Title: Altered behavior in mice with deletion of the alpha2-antiplasmin gene.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI747498 (e-PCR)
- UniSTS:180252

NoName (e-PCR)
- UniSTS:236636

NoName (e-PCR)
- UniSTS:236640

Serpinf2 (e-PCR), detects polymorphism
- UniSTS:525944

Z36774 (e-PCR)
- UniSTS:125930

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protease binding	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acute-phase response	IEA Inferred from Electronic Annotation more info
involved_in blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in collagen fibril organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of blood vessel diameter homeostasis by renin-angiotensin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of fibrinolysis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of fibrinolysis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of plasminogen activation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of plasminogen activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collagen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stress fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transforming growth factor beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transforming growth factor beta production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of fibrinogen complex	IEA Inferred from Electronic Annotation more info
part_of fibrinogen complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-2-antiplasmin

Names: alpha-2-AP; alpha-2-PI; alpha-2-plasmin inhibitor; pigment epithelium derived factor; plasmin inhibitor alpha 2; serine (or cysteine) proteinase inhibitor, clade F, member 2; serpin F2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008878.2 → NP_032904.1 alpha-2-antiplasmin precursor

See identical proteins and their annotated locations for NP_032904.1

Status: VALIDATED

Source sequence(s)

AA269351, AK077563, AL591496, GQ896353

Consensus CDS

CCDS25046.1

UniProtKB/Swiss-Prot

Q61247

UniProtKB/TrEMBL

Q5ND36

Related

ENSMUSP00000048704.3, ENSMUST00000043696.9

Conserved Domains (1) summary

cd02053
Location:82 → 433

alpha2AP; Alpha2-antiplasmin (alpha2AP) is the primary inhibitor of plasmin, a proteinase that digests fibrin, the main component of blood clots. Alpha2-Antiplasmin forms an inactive 1 : 1 stoichiometric complex with plasmin. It also rapidly crosslinks to fibrin ...