Epha6 Eph receptor A6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Epha6provided by MGI
Official Full Name: Eph receptor A6provided by MGI
Primary source: MGI:MGI:108034
See related: Ensembl:ENSMUSG00000055540 AllianceGenome:MGI:108034
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ehk2; EHK-2; Hek12; m-ehk2
Summary: Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axon guidance and ephrin receptor signaling pathway. Predicted to be located in nucleoplasm. Predicted to be active in dendrite and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; endometrium; male reproductive gland or organ; and sensory organ. Orthologous to human EPHA6 (EPH receptor A6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in frontal lobe adult (RPKM 1.8), cortex adult (RPKM 1.3) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C1.3; 16 34.83 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (59473424..60431196, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (59641433..60610911, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EPHA6, a gene implicated in retinal axon guidance, is one of HMX1 targets in eye development.
Title: A dimerized HMX1 inhibits EPHA6/epha4b in mouse and zebrafish retinas.
These findings suggest that EphA6, in line with a number of other Eph receptors and their ephrin ligands, is involved in neural circuits underlying aspects of learning and memory.
Title: Learning and memory impairment in Eph receptor A6 knockout mice.
HOXA13 directly regulates EphA6 and EphA7 in the developing genital tubercle.
Title: HOXA13 directly regulates EphA6 and EphA7 expression in the genital tubercle vascular endothelia.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

General gene information

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Markers

Epha6 (e-PCR), detects polymorphism
- UniSTS:495884

D16Mit148 (e-PCR), detects polymorphism
- UniSTS:127781

MTH697 (e-PCR)
- UniSTS:127817

D16Mit185.2 (e-PCR), detects polymorphism
- UniSTS:127818

D11Rat85 (e-PCR), detects polymorphism
- UniSTS:226431

NoName (e-PCR)
- UniSTS:548482

NoName (e-PCR)
- UniSTS:548483

D16Mit92 (e-PCR), detects polymorphism
- UniSTS:127929

Sample_03.Seq (e-PCR)
- UniSTS:125629

Epha6 (e-PCR), detects polymorphism
- UniSTS:527337

Epha6 (e-PCR), detects polymorphism
- UniSTS:266989

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase collagen receptor activity	IEA Inferred from Electronic Annotation more info
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane-ephrin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane-ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in brain-derived neurotrophic factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ephrin type-A receptor 6

Names: EPH homology kinase 2

NP_031964.2

EC 2.7.10.1

XP_006521850.1

EC 2.7.10.1

XP_011244128.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007938.2 → NP_031964.2 ephrin type-A receptor 6

See identical proteins and their annotated locations for NP_031964.2

Status: VALIDATED

Source sequence(s)

AC118603, AC122318, AC131707, AC133940, AC134526, AC154212, AC154473, AC154632, CT009682

Consensus CDS

CCDS28260.2

UniProtKB/Swiss-Prot

B9EIV2, Q62413, Q8CCN2

UniProtKB/TrEMBL

G1K381

Related

ENSMUSP00000066734.7, ENSMUST00000068860.13

Conserved Domains (9) summary

cd09547
Location:1055 → 1118

SAM_EPH-A6; SAM domain of EPH-A6 subfamily of tyrosine kinase receptors

smart00454
Location:1052 → 1119

SAM; Sterile alpha motif

cd10484
Location:128 → 300

EphR_LBD_A6; Ligand Binding Domain of Ephrin type-A Receptor 6

cd00063
Location:549 → 628

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:720 → 1028

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam00041
Location:427 → 521

fn3; Fibronectin type III domain

pfam07699
Location:370 → 406

GCC2_GCC3; GCC2 and GCC3

pfam07714
Location:725 → 1024

Pkinase_Tyr; Protein tyrosine kinase

pfam14575
Location:648 → 720

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

59473424..60431196 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521787.4 → XP_006521850.1 ephrin type-A receptor 6 isoform X1

UniProtKB/Swiss-Prot

B9EIV2, Q62413, Q8CCN2

Conserved Domains (7) summary

cd09547
Location:899 → 962

SAM_EPH-A6; SAM domain of EPH-A6 subfamily of tyrosine kinase receptors

cd00063
Location:393 → 472

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:564 → 872

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam07699
Location:214 → 250

Ephrin_rec_like; Putative ephrin-receptor like

pfam00041
Location:271 → 361

fn3; Fibronectin type III domain

pfam14575
Location:492 → 564

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

cl02704
Location:1 → 144

EphR_LBD; Ligand Binding Domain of Ephrin Receptors
XM_011245826.4 → XP_011244128.1 ephrin type-A receptor 6 isoform X2

Conserved Domains (1) summary

cd10484
Location:128 → 300

EphR_LBD_A6; Ligand Binding Domain of Ephrin type-A Receptor 6