Spta1 spectrin, alpha, erythrocytic 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Spta1provided by RGD
Official Full Name: spectrin, alpha, erythrocytic 1provided by RGD
Primary source: RGD:1305194
See related: EnsemblRapid:ENSRNOG00000003537 AllianceGenome:RGD:1305194
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Spna1
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in actin cytoskeleton organization. Predicted to act upstream of or within several processes, including lymphocyte homeostasis; positive regulation of T cell proliferation; and regulation of cell shape. Located in axon and cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in hereditary spherocytosis and hereditary spherocytosis type 3. Orthologous to human SPTA1 (spectrin alpha, erythrocytic 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 408.7), Heart (RPKM 172.9) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 52

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (88735833..88811697)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (86203504..86279371)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (92264231..92340091)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cytoskeletal protein SPTA1 mediating the decrease in erectile function induced by high-fat diet via Hippo signaling pathway.
Title: Cytoskeletal protein SPTA1 mediating the decrease in erectile function induced by high-fat diet via Hippo signaling pathway.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament capping	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lymphocyte homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within plasma membrane organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within porphyrin-containing compound biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell shape	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cortical cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cuticular plate	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of spectrin	ISO Inferred from Sequence Orthology more info
located_in spectrin-associated cytoskeleton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: spectrin alpha chain, erythrocytic 1

Names: erythroid spectrin alpha; spectrin alpha chain, erythrocyte; spectrin, alpha, erythrocytic 1 (elliptocytosis 2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011908.4 → NP_001011908.3 spectrin alpha chain, erythrocytic 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

D4A678, F7FC39, Q6XDA1

Related

ENSRNOP00000061853.4, ENSRNOT00000066509.6

Conserved Domains (6) summary

smart00150
Location:900 → 956

SPEC; Spectrin repeats

COG5126
Location:2265 → 2379

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00176
Location:1606 → 1817

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00435
Location:1080 → 1177

Spectrin; Spectrin repeat

pfam08726
Location:2346 → 2414

EFhand_Ca_insen; Ca2+ insensitive EF hand

cl17036
Location:980 → 1031

SH3; Src Homology 3 domain superfamily