Prx periaxin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prxprovided by RGD
Official Full Name: periaxinprovided by RGD
Primary source: RGD:619960
See related: EnsemblRapid:ENSRNOG00000018369 AllianceGenome:RGD:619960
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Involved in axon ensheathment and nerve development. Predicted to be located in cytosol; nuclear speck; and plasma membrane. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 3 and Charcot-Marie-Tooth disease type 4F. Orthologous to human PRX (periaxin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 225.5), Muscle (RPKM 76.9) and 4 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 1q21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (91912669..91934754)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (82785082..82807154)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (84302074..84324560)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ezrin interacts with L-periaxin by the ""head to head and tail to tail"" mode and influences the location of L-periaxin in Schwann cell RSC96.
Title: Ezrin interacts with L-periaxin by the "head to head and tail to tail" mode and influences the location of L-periaxin in Schwann cell RSC96.
the two periaxin isoforms interacted in the cytoplasm through the PDZ domain, and their interaction prevented the homodimerization of L-periaxin. S-periaxin may regulate the function of L-periaxin in Schwann cells
Title: L-periaxin interacts with S-periaxin through its PDZ domain.
dual mechanism for periaxin regulation and suggest that the role of Krox-20 is to amplify an earlier Krox-20-independent activation of the periaxin gene in schwann cells.
Title: Regulation of the myelin gene periaxin provides evidence for Krox-20-independent myelin-related signalling in Schwann cells.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axon ensheathment	IEP Inferred from Expression Pattern more info	PubMed
involved_in nerve development	IEP Inferred from Expression Pattern more info	PubMed
involved_in peripheral nervous system myelin formation	ISO Inferred from Sequence Orthology more info
involved_in peripheral nervous system myelin maintenance	IBA Inferred from Biological aspect of Ancestor more info
involved_in peripheral nervous system myelin maintenance	ISO Inferred from Sequence Orthology more info
involved_in regulation of RNA splicing	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in transmission of nerve impulse	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: periaxin

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023976.2 → NP_076466.2 periaxin

See identical proteins and their annotated locations for NP_076466.2

Status: PROVISIONAL

Source sequence(s)

Z29649

UniProtKB/Swiss-Prot

Q63425

UniProtKB/TrEMBL

A0A8I6GHF6

Related

ENSRNOP00000110948.1, ENSRNOT00000146700.1

Conserved Domains (2) summary

smart00228
Location:17 → 98

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam02389
Location:612 → 723

Cornifin; Cornifin (SPRR) family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

91912669..91934754

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091780.2 → XP_038947708.1 periaxin isoform X1

UniProtKB/TrEMBL

A0A8I6GHF6, A6J9D2, G3V8D2

Conserved Domains (2) summary

smart00228
Location:17 → 98

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam02389
Location:612 → 723

Cornifin; Cornifin (SPRR) family
XM_063274955.1 → XP_063131025.1 periaxin isoform X1

UniProtKB/TrEMBL

A0A8I6GHF6, A6J9D2, G3V8D2