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    Wbp4 WW domain binding protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114765, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wbp4provided by RGD
    Official Full Name
    WW domain binding protein 4provided by RGD
    Primary source
    RGD:620033
    See related
    EnsemblRapid:ENSRNOG00000011678 AllianceGenome:RGD:620033
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fbp21
    Summary
    Predicted to enable RNA binding activity and proline-rich region binding activity. Predicted to be involved in mRNA cis splicing, via spliceosome. Predicted to be located in nuclear speck. Predicted to be part of U2-type precatalytic spliceosome. Orthologous to human WBP4 (WW domain binding protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 103.1), Thymus (RPKM 101.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wbp4 in Genome Data Viewer
    Location:
    15q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (61271774..61299740, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (54862700..54890668, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (61745989..61772516, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L15, pseudogene 1 Neighboring gene kelch repeat and BTB domain containing 6 Neighboring gene uncharacterized LOC134481995 Neighboring gene transfer RNA glutamic acid (anticodon UUC) 8 Neighboring gene microfibrillar-associated protein 1-like Neighboring gene E74 like ETS transcription factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure and function of the two tandem WW domains of the pre-mRNA splicing factor FBP21 (formin-binding protein 21). Huang X, et al. J Biol Chem, 2009 Sep 11. PMID 19592703, Free PMC Article
    2. WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif. Bedford MT, et al. Proc Natl Acad Sci U S A, 1998 Sep 1. PMID 9724750, Free PMC Article
    3. A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens 2 as a marker of epithelioid "pup" smooth muscle cells and a participant in carotid neointimal formation. Adams LD, et al. Arterioscler Thromb Vasc Biol, 1999 Nov. PMID 10559001
    4. Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation. Bertram K, et al. Cell, 2017 Aug 10. PMID 28781166
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proline-rich region binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proline-rich region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA cis splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA cis splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA cis splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of U2-type precatalytic spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type precatalytic spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WW domain-binding protein 4
    Names
    WBP-4
    WW domain binding protein 4 (formin binding protein 21)
    WW domain-containing-binding protein 4
    formin-binding protein 21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053766.2 → NP_446218.1  WW domain-binding protein 4

      See identical proteins and their annotated locations for NP_446218.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      Q5HZF2
      UniProtKB/TrEMBL
      A0A8L2Q7K4, A6HTZ4
      Related
      ENSRNOP00000076733.1, ENSRNOT00000111542.2
      Conserved Domains (2) summary
      pfam06220
      Location:8 → 42
      zf-U1; U1 zinc finger
      pfam00397
      Location:168 → 193
      WW; WW domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      61271774..61299740 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008770840.4 → XP_008769062.1  WW domain-binding protein 4 isoform X1

      See identical proteins and their annotated locations for XP_008769062.1

      UniProtKB/TrEMBL
      A0A8I5Y9P1, A0A8L2Q7K4
      Related
      ENSRNOP00000077691.1, ENSRNOT00000102266.2
      Conserved Domains (2) summary
      cd00201
      Location:138 → 165
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:179 → 204
      WW; WW domain

    2. XM_063273906.1 → XP_063129976.1  WW domain-binding protein 4 isoform X4

    3. XM_063273904.1 → XP_063129974.1  WW domain-binding protein 4 isoform X2

    4. XM_063273905.1 → XP_063129975.1  WW domain-binding protein 4 isoform X3

    5. XM_063273907.1 → XP_063129977.1  WW domain-binding protein 4 isoform X5

    RNA

    1. XR_010057795.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5HZF2.1 GenPept UniProtKB/Swiss-Prot:Q5HZF2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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