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    Klrb1b killer cell lectin like receptor B1B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25192, updated on 9-Dec-2024

    Summary

    Official Symbol
    Klrb1bprovided by RGD
    Official Full Name
    killer cell lectin like receptor B1Bprovided by RGD
    Primary source
    RGD:2975
    See related
    EnsemblRapid:ENSRNOG00000071746 AllianceGenome:RGD:2975
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nkrp1b; Nkr-p1b
    Summary
    Predicted to enable signaling receptor activity. Predicted to be involved in regulation of natural killer cell mediated cytotoxicity. Predicted to be located in membrane. Predicted to be active in cell surface and plasma membrane. Orthologous to human KLRB1 (killer cell lectin like receptor B1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 76.9), Lung (RPKM 37.3) and 7 other tissues See more
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    Genomic context

    See Klrb1b in Genome Data Viewer
    Location:
    4q42
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (163634357..163647629, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (161948259..161961537, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (162012653..162025090, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486846 Neighboring gene uncharacterized LOC134486847 Neighboring gene uncharacterized LOC120102404 Neighboring gene C-type lectin domain family 2 member D2 like 3 Neighboring gene uncharacterized LOC100912974 Neighboring gene C-type lectin domain family 2 member D2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of natural killer cell mediated cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    killer cell lectin-like receptor subfamily B member 1B
    Names
    CD161 antigen-like family member B
    natural killer cell surface protein NKR-P1B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173292.3NP_775414.2  killer cell lectin-like receptor subfamily B member 1B

      See identical proteins and their annotated locations for NP_775414.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      A4KWA1, Q62983
      UniProtKB/TrEMBL
      A0A8I6AB27, B5U216
      Related
      ENSRNOP00000095158.1, ENSRNOT00000111200.2
      Conserved Domains (1) summary
      cd03593
      Location:94212
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      163634357..163647629 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)