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    Osbpl2 oxysterol binding protein-like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296461, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Osbpl2provided by RGD
    Official Full Name
    oxysterol binding protein-like 2provided by RGD
    Primary source
    RGD:1311312
    See related
    EnsemblRapid:ENSRNOG00000057756 AllianceGenome:RGD:1311312
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cholesterol binding activity; lipid transfer activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including intracellular cholesterol transport; protein homotetramerization; and regulation of synaptic vesicle priming. Predicted to be located in cytoplasmic side of plasma membrane and lipid droplet. Predicted to be active in several cellular components, including cytosol; glutamatergic synapse; and perinuclear endoplasmic reticulum. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 67. Orthologous to human OSBPL2 (oxysterol binding protein like 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 89.3), Thymus (RPKM 83.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Osbpl2 in Genome Data Viewer
    Location:
    3q43
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (187585372..187633827)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (167210945..167256219)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (175493650..175538965)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosome-associated GTPase 2 Neighboring gene histamine receptor H3 Neighboring gene uncharacterized LOC120101831 Neighboring gene ADRM1 26S proteasome ubiquitin receptor Neighboring gene laminin subunit alpha 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Proteomics for Studying the Effects of Ketogenic Diet Against Lithium Chloride/Pilocarpine Induced Epilepsy in Rats. Zheng YQ, et al. Front Neurosci, 2020. PMID 33132826, Free PMC Article
    2. ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P(2)). Wang H, et al. Mol Cell, 2019 Feb 7. PMID 30581148
    3. OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids. Hynynen R, et al. J Lipid Res, 2009 Jul. PMID 19224871, Free PMC Article
    4. The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket. Suchanek M, et al. Biochem J, 2007 Aug 1. PMID 17428193, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108916

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cholesterol transfer activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol transfer activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intermembrane lipid transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in plasma membrane organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of presynaptic cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of synaptic vesicle priming ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynaptic active zone cytoplasmic component IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    oxysterol-binding protein-related protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013079.1 → NP_001013097.1  oxysterol-binding protein-related protein 2

      See identical proteins and their annotated locations for NP_001013097.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091208
      UniProtKB/TrEMBL
      A0A0G2K9B7, A6KMB6, Q5BK47
      Conserved Domains (1) summary
      pfam01237
      Location:74 → 473
      Oxysterol_BP; Oxysterol-binding protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      187585372..187633827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283423.1 → XP_063139493.1  oxysterol-binding protein-related protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K9B7, A6KMB6, Q5BK47

    2. XM_039104663.2 → XP_038960591.1  oxysterol-binding protein-related protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K9B7, A6KMB6, Q5BK47
      Related
      ENSRNOP00000092392.2, ENSRNOT00000114663.2
      Conserved Domains (1) summary
      pfam01237
      Location:74 → 473
      Oxysterol_BP; Oxysterol-binding protein

    3. XM_039104664.1 → XP_038960592.1  oxysterol-binding protein-related protein 2 isoform X3

      Related
      ENSRNOP00000074937.2, ENSRNOT00000087356.3
      Conserved Domains (1) summary
      pfam01237
      Location:43 → 442
      Oxysterol_BP; Oxysterol-binding protein

    4. XM_063283422.1 → XP_063139492.1  oxysterol-binding protein-related protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AI28
    Nucleotide Protein Strain
    Heading Accession and Version

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