Etfdh electron transfer flavoprotein dehydrogenase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Etfdhprovided by RGD
Official Full Name: electron transfer flavoprotein dehydrogenaseprovided by RGD
Primary source: RGD:735052
See related: EnsemblRapid:ENSRNOG00000009538 AllianceGenome:RGD:735052
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables electron transfer activity and iron-sulfur cluster binding activity. Predicted to be involved in electron transport chain; fatty acid beta-oxidation using acyl-CoA dehydrogenase; and response to oxidative stress. Located in mitochondrial membrane. Human ortholog(s) of this gene implicated in multiple acyl-CoA dehydrogenase deficiency. Orthologous to human ETFDH (electron transfer flavoprotein dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 1358.2), Liver (RPKM 820.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q33

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (167038707..167060758, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (164740547..164762754, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (178367547..178389641, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A 32 amino acid peptide was a mitochondrial targeting peptide, and both FAD and iron-sulfur cluster were inserted properly into the recombinant enzyme.
Title: cDNA cloning, functional expression and cellular localization of rat liver mitochondrial electron-transfer flavoprotein-ubiquinone oxidoreductase protein.

Submit: New GeneRIF Correction

General gene information

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Markers

Etfdh (e-PCR), detects polymorphism
- UniSTS:506888

RH128555 (e-PCR)
- UniSTS:211863

AV001013 (e-PCR)
- UniSTS:178848

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables 4 iron, 4 sulfur cluster binding	ISO Inferred from Sequence Orthology more info
enables electron transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables electron transfer activity	ISO Inferred from Sequence Orthology more info
enables electron-transferring-flavoprotein dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables electron-transferring-flavoprotein dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables electron-transferring-flavoprotein dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables flavin adenine dinucleotide binding	ISO Inferred from Sequence Orthology more info
enables iron-sulfur cluster binding	IDA Inferred from Direct Assay more info	PubMed
enables iron-sulfur cluster binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables quinone binding	ISO Inferred from Sequence Orthology more info
enables ubiquinone binding	IEA Inferred from Electronic Annotation more info
enables ubiquinone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in electron transport chain	IBA Inferred from Biological aspect of Ancestor more info
involved_in electron transport chain	ISO Inferred from Sequence Orthology more info
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase	IEA Inferred from Electronic Annotation more info
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase	ISO Inferred from Sequence Orthology more info
involved_in respiratory electron transport chain	IEA Inferred from Electronic Annotation more info
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

Names: ETF dehydrogenase; ETF-QO; ETF-ubiquinone oxidoreductase; electron transferring flavoprotein dehydrogenase

NP_942037.2

EC 1.5.5.1

XP_006232569.1

EC 1.5.5.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198742.2 → NP_942037.2 electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor

See identical proteins and their annotated locations for NP_942037.2

Status: PROVISIONAL

Source sequence(s)

BC081890

UniProtKB/Swiss-Prot

Q6UPE1

UniProtKB/TrEMBL

F2W8A8, Q66HF3

Related

ENSRNOP00000077926.2, ENSRNOT00000105634.2

Conserved Domains (3) summary

COG0644
Location:66 → 528

FixC; Dehydrogenase (flavoprotein) [Energy production and conversion]

pfam05187
Location:511 → 614

ETF_QO; Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S

cl21454
Location:67 → 261

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

167038707..167060758 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006232507.2 → XP_006232569.1 electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial isoform X1

UniProtKB/Swiss-Prot

Q6UPE1

UniProtKB/TrEMBL

F7ELJ5

Related

ENSRNOP00000013262.5, ENSRNOT00000013262.8

Conserved Domains (3) summary

COG0644
Location:66 → 479

FixC; Dehydrogenase (flavoprotein) [Energy production and conversion]

pfam05187
Location:462 → 565

ETF_QO; Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S

cl21454
Location:67 → 216

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins