S100b S100 calcium binding protein B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: S100bprovided by RGD
Official Full Name: S100 calcium binding protein Bprovided by RGD
Primary source: RGD:3615
See related: EnsemblRapid:ENSRNOG00000001295 AllianceGenome:RGD:3615
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: S100P
Summary: Enables RAGE receptor binding activity; identical protein binding activity; and metal ion binding activity. Involved in several processes, including long-term synaptic potentiation; negative regulation of skeletal muscle cell differentiation; and positive regulation of myelination. Located in extracellular space. Used to study demyelinating disease. Biomarker of several diseases, including bipolar disorder; borna disease; brain disease (multiple); depressive disorder; and sleep apnea. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; aspergillosis; and schizophrenia. Orthologous to human S100B (S100 calcium binding protein B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 2647.5), Adrenal (RPKM 351.8) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (12372345..12381159, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (12372866..12381619, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (13130633..13142856, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Autocrine S100B in astrocytes promotes VEGF-dependent inflammation and oxidative stress and causes impaired neuroprotection.
Title: Autocrine S100B in astrocytes promotes VEGF-dependent inflammation and oxidative stress and causes impaired neuroprotection.
Pathophysiological aspects of neonatal anoxia and temporal expression of S100beta in different brain regions.
Title: Pathophysiological aspects of neonatal anoxia and temporal expression of S100β in different brain regions.
The Role of the C-Terminal Lysine of S100P in S100P-Induced Cell Migration and Metastasis.
Title: The Role of the C-Terminal Lysine of S100P in S100P-Induced Cell Migration and Metastasis.
Glycolipid toxicity induces osteogenic dysfunction via the TLR4/S100B pathway.
Title: Glycolipid toxicity induces osteogenic dysfunction via the TLR4/S100B pathway.
Effects of S100B neutralization on the long-term cognitive impairment and neuroinflammatory response in an animal model of sepsis.
Title: Effects of S100B neutralization on the long-term cognitive impairment and neuroinflammatory response in an animal model of sepsis.
Commentary on ""Novel Interaction of the Dopamine D2 Receptor and the Ca(2+) Binding Protein S100B: Role in D2 Receptor Function"".
Title: Commentary on "Novel Interaction of the Dopamine D2 Receptor and the Ca(2+) Binding Protein S100B: Role in D2 Receptor Function".
miR-135b-dependent downregulation of S100B promotes neural stem cell differentiation in a hypoxia/ischemia-induced cerebral palsy rat model.
Title: miR-135b-dependent downregulation of S100B promotes neural stem cell differentiation in a hypoxia/ischemia-induced cerebral palsy rat model.
The neuroprotective effect of sevoflurane is associated with defense mechanisms against free radical-induced oxidative stress and inhibition of apoptosis. S100B protein correlated with oxidative stress and the apoptosis signaling pathways.
Title: Sevoflurane reduces ischemic brain injury in rats with diet and streptozotocin-induced diabetes.
the present study identified that one of the lineages of S100beta-positive cells is a SOX10-positive one and that SOX10-positive cells express pituitary stem/progenitor cell marker genes.
Title: SOX10-positive cells emerge in the rat pituitary gland during late embryogenesis and start to express S100β.
These data indicated that S100B is a novel regulator for vascular remodeling following injury and may serve as a potential biomarker for vascular damage or drug target for treating proliferative vascular diseases.
Title: S100B promotes injury-induced vascular remodeling through modulating smooth muscle phenotype.

Submit: New GeneRIF Correction See all GeneRIFs (87)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA945753 (e-PCR)
- UniSTS:250429

S100b (e-PCR), detects polymorphism
- UniSTS:259138

RH94706 (e-PCR)
- UniSTS:119953

D20Wox6 (e-PCR)
- UniSTS:518649

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RAGE receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables RAGE receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RAGE receptor binding	ISO Inferred from Sequence Orthology more info
enables S100 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables S100 protein binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables tau protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in adaptive thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in adaptive thermogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in astrocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in learning or memory	ISO Inferred from Sequence Orthology more info
involved_in learning or memory	ISS Inferred from Sequence or Structural Similarity more info
involved_in long-term synaptic potentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within memory	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of skeletal muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in response to anesthetic	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to methylmercury	IEP Inferred from Expression Pattern more info	PubMed
involved_in sympathetic neuron projection extension	ISO Inferred from Sequence Orthology more info
involved_in sympathetic neuron projection extension	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein S100-B

Names: S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein, beta (neural); S100 protein, beta polypeptide, neural

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013191.2 → NP_037323.1 protein S100-B

See identical proteins and their annotated locations for NP_037323.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

P04631

UniProtKB/TrEMBL

A6JKD9

Related

ENSRNOP00000001743.4, ENSRNOT00000001743.4

Conserved Domains (1) summary

cd05027
Location:2 → 89

S-100B; S-100B domain found in proteins similar to S100B. S100B is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which this ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

12372345..12381159 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008772868.3 → XP_008771090.1 protein S100-B isoform X1

See identical proteins and their annotated locations for XP_008771090.1

UniProtKB/Swiss-Prot

P04631

UniProtKB/TrEMBL

A6JKD9

Conserved Domains (1) summary

cd05027
Location:2 → 89

S-100B; S-100B domain found in proteins similar to S100B. S100B is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which this ...
XM_017601568.3 → XP_017457057.1 protein S100-B isoform X1

UniProtKB/Swiss-Prot

P04631

UniProtKB/TrEMBL

A6JKD9

Conserved Domains (1) summary

cd05027
Location:2 → 89

S-100B; S-100B domain found in proteins similar to S100B. S100B is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which this ...
XM_063278986.1 → XP_063135056.1 protein S100-B isoform X1

UniProtKB/Swiss-Prot

P04631