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    Ankra2 ankyrin repeat family A member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294679, updated on 27-Nov-2024

    Summary

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    Symbol
    Ankra2provided by RGD
    Full Name
    ankyrin repeat family A member 2provided by RGD
    Primary source
    RGD:1303108
    See related
    EnsemblRapid:ENSRNOG00000048118 AllianceGenome:RGD:1303108
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ANKRA
    Summary
    Predicted to enable enzyme binding activity and low-density lipoprotein particle receptor binding activity. Predicted to be involved in regulation of gene expression and regulation of protein-containing complex assembly. Predicted to be located in cytosol and membrane. Predicted to be part of 3M complex. Predicted to be active in nucleus. Orthologous to human ANKRA2 (ankyrin repeat family A member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 70.9), Kidney (RPKM 65.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ankra2 in Genome Data Viewer
    Location:
    2q12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (31347158..31358002)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (29612867..29623748)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (82407601..82418229, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485583 Neighboring gene UTP15, small subunit processome component Neighboring gene uncharacterized LOC120100679 Neighboring gene basic transcription factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and functional characterization of ankyrin-repeat family protein ANKRA as a protein interacting with BKCa channel. Lim HH, et al. Mol Biol Cell, 2005 Mar. PMID 15616191, Free PMC Article
    2. Characterization of ANKRA, a novel ankyrin repeat protein that interacts with the cytoplasmic domain of megalin. Rader K, et al. J Am Soc Nephrol, 2000 Dec. PMID 11095640
    3. Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock. Xu C, et al. Sci Signal, 2012 May 29. PMID 22649097
    4. Class II histone deacetylases confer signal responsiveness to the ankyrin-repeat proteins ANKRA2 and RFXANK. McKinsey TA, et al. Mol Biol Cell, 2006 Jan. PMID 16236793, Free PMC Article
    5. Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8. Nie J, et al. Structure, 2015 Apr 7. PMID 25752541

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ANKRA could modulate the excitability of neurons by binding directly to endogenous BKCa channel and altering its gating kinetics in a calcium-dependent manner
      Title: Identification and functional characterization of ankyrin-repeat family protein ANKRA as a protein interacting with BKCa channel.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94130

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of 3M complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat family A protein 2
    Names
    SLO-interacting ankyrin-containing protein
    ankyrin repeat family A protein 2-like
    ankyrin repeat, family A (RFXANK-like), 2
    ankyrin-repeat family A protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001416756.1 → NP_001403685.1  ankyrin repeat family A protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6I539

    2. NM_207595.2 → NP_997478.1  ankyrin repeat family A protein 2 isoform 1

      See identical proteins and their annotated locations for NP_997478.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      M0R870, Q6Q287
      Related
      ENSRNOP00000107996.1, ENSRNOT00000147507.1
      Conserved Domains (2) summary
      sd00045
      Location:181 → 212
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:186 → 276
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      31347158..31358002
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101921.2 → XP_038957849.1  ankyrin repeat family A protein 2 isoform X2

      Conserved Domains (3) summary
      COG0666
      Location:52 → 252
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:128 → 159
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:133 → 223
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_063281493.1 → XP_063137563.1  ankyrin repeat family A protein 2 isoform X1

      Related
      ENSRNOP00000098976.1, ENSRNOT00000136863.1

    3. XM_063281494.1 → XP_063137564.1  ankyrin repeat family A protein 2 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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