Lpar2 lysophosphatidic acid receptor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lpar2provided by RGD
Official Full Name: lysophosphatidic acid receptor 2provided by RGD
Primary source: RGD:1561336
See related: EnsemblRapid:ENSRNOG00000090786 AllianceGenome:RGD:1561336
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Edg4; RGD1561336
Summary: Predicted to enable G protein-coupled receptor activity and PDZ domain binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within G protein-coupled receptor signaling pathway; positive regulation of MAPK cascade; and positive regulation of Rho protein signal transduction. Predicted to be located in cell surface and endocytic vesicle. Predicted to be active in cytoplasm; glutamatergic synapse; and presynaptic active zone membrane. Orthologous to human LPAR2 (lysophosphatidic acid receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 44.7), Kidney (RPKM 38.9) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p14

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (19625974..19633905, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (19592067..19599998, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (21343313..21348913, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data showed that lysophosphatidic acid receptors LPA1-3, are phosphoproteins whose phosphorylation state is modulated by the natural agonist, LPA.
Title: Phosphorylation and Internalization of Lysophosphatidic Acid Receptors LPA1, LPA2, and LPA3.
These findings identify ATX and LPA2 as radiation-regulated genes that appear to play a physiological role in DNA repair.
Title: The autotaxin-LPA2 GPCR axis is modulated by γ-irradiation and facilitates DNA damage repair.

Submit: New GeneRIF Correction

General gene information

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Markers

PMC134025P1 (e-PCR)
- UniSTS:270717

PMC134025P2 (e-PCR)
- UniSTS:270718

PMC134025P3 (e-PCR)
- UniSTS:270719

RH132663 (e-PCR)
- UniSTS:215946

RH136676 (e-PCR)
- UniSTS:215946

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables lysophosphatidic acid receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lysophosphatidic acid receptor 2

Names: endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4; pre-B-cell leukemia transcription factor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109109.2 → NP_001102579.2 lysophosphatidic acid receptor 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A0A0G2K505

Related

ENSRNOP00000105420.1, ENSRNOT00000137486.1

Conserved Domains (2) summary

cd14964
Location:31 → 57

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:30 → 303

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily