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    Tent4a terminal nucleotidyltransferase 4A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306672, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tent4aprovided by RGD
    Official Full Name
    terminal nucleotidyltransferase 4Aprovided by RGD
    Primary source
    RGD:1307356
    See related
    EnsemblRapid:ENSRNOG00000017613 AllianceGenome:RGD:1307356
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pols; Papd7
    Summary
    Predicted to enable guanylyltransferase activity and poly(A) RNA polymerase activity. Predicted to be involved in RNA metabolic process; regulation of mRNA stability; and response to xenobiotic stimulus. Predicted to be located in Golgi apparatus; nuclear membrane; and nucleoplasm. Predicted to be part of TRAMP complex. Predicted to be active in nucleolus. Orthologous to human TENT4A (terminal nucleotidyltransferase 4A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 45.1), Kidney (RPKM 42.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tent4a in Genome Data Viewer
    Location:
    1p11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (35594380..35627836)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (33765949..33799405)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (36400056..36433238)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene steroid 5 alpha-reductase 1 Neighboring gene small nucleolar RNA SNORA24 Neighboring gene Rab geranylgeranyltransferase subunit beta, pseudogene 2 Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 18 Neighboring gene Myc binding protein, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mixed tailing by TENT4A and TENT4B shields mRNA from rapid deadenylation. Lim J, et al. Science, 2018 Aug 17. PMID 30026317
    2. The topoisomerase-related function gene TRF4 affects cellular sensitivity to the antitumor agent camptothecin. Walowsky C, et al. J Biol Chem, 1999 Mar 12. PMID 10066793
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA 3' uridylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in polyadenylation-dependent ncRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of 3'-UTR-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of TRAMP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    terminal nucleotidyltransferase 4A
    Names
    DNA polymerase sigma
    PAP associated domain containing 7
    non-canonical poly(A) RNA polymerase PAPD7
    poly(A) RNA polymerase D7, non-canonical
    polymerase (DNA directed) sigma
    NP_001100803.2
    NP_001402773.1
    XP_038966019.1
    XP_063144175.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107333.3 → NP_001100803.2  terminal nucleotidyltransferase 4A isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      D3ZSY1

    2. NM_001415844.1 → NP_001402773.1  terminal nucleotidyltransferase 4A isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      Related
      ENSRNOP00000023712.7, ENSRNOT00000023712.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      35594380..35627836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288105.1 → XP_063144175.1  terminal nucleotidyltransferase 4A isoform X1

      Related
      ENSRNOP00000103767.1, ENSRNOT00000128302.1

    2. XM_039110091.2 → XP_038966019.1  terminal nucleotidyltransferase 4A isoform X2

      UniProtKB/TrEMBL
      A6JV21
      Conserved Domains (2) summary
      COG5260
      Location:2 → 295
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
      pfam05109
      Location:370 → 473
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    Nucleotide Protein Strain
    Heading Accession and Version

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