Dis3l2 DIS3-like 3'-5' exoribonuclease 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dis3l2provided by RGD
Official Full Name: DIS3-like 3'-5' exoribonuclease 2provided by RGD
Primary source: RGD:1560168
See related: EnsemblRapid:ENSRNOG00000018931 AllianceGenome:RGD:1560168
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1560168
Summary: Predicted to enable 3'-5'-RNA exonuclease activity; magnesium ion binding activity; and poly(U) RNA binding activity. Predicted to be involved in several processes, including RNA catabolic process; mitotic sister chromatid separation; and stem cell population maintenance. Predicted to be located in cytoplasm. Predicted to be active in P-body. Human ortholog(s) of this gene implicated in Perlman syndrome and nephroblastoma. Orthologous to human DIS3L2 (DIS3 like 3'-5' exoribonuclease 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 119.1), Brain (RPKM 106.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q35

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (94802056..95184523)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (87355409..87736616)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (93767837..94161106)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3'-5'-RNA exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3'-5'-RNA exonuclease activity	ISO Inferred from Sequence Orthology more info
enables RNA nuclease activity	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables poly(U) RNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in mRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in miRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in miRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in mitotic sister chromatid separation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in nuclear-transcribed mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in polyuridylation-dependent mRNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in stem cell population maintenance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
located_in P-body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DIS3-like exonuclease 2

Names: DIS3 mitotic control homolog-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109007.2 → NP_001102477.2 DIS3-like exonuclease 2 isoform 1

See identical proteins and their annotated locations for NP_001102477.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

CH474004

UniProtKB/TrEMBL

A0A0G2K6W6, A6JWJ8

Related

ENSRNOP00000073968.2, ENSRNOT00000084590.3

Conserved Domains (2) summary

COG0557
Location:238 → 824

VacB; Exoribonuclease R [Transcription]

pfam17216
Location:50 → 159

Rrp44_CSD1; Rrp44-like cold shock domain
NM_001172159.1 → NP_001165630.1 DIS3-like exonuclease 2 isoform 2

See identical proteins and their annotated locations for NP_001165630.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.

Source sequence(s)

CH474004

UniProtKB/TrEMBL

A6JWJ9, D3ZIL9

Related

ENSRNOP00000025779.4, ENSRNOT00000025779.7

Conserved Domains (2) summary

COG0557
Location:224 → 810

VacB; Exoribonuclease R [Transcription]

pfam00773
Location:369 → 717

RNB; RNB domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

94802056..95184523

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039083980.2 → XP_038939908.1 DIS3-like exonuclease 2 isoform X3

Conserved Domains (2) summary

COG0557
Location:238 → 746

VacB; Exoribonuclease R [Transcription]

pfam17216
Location:50 → 159

Rrp44_CSD1; Rrp44-like cold shock domain
XM_063267518.1 → XP_063123588.1 DIS3-like exonuclease 2 isoform X4

Related

ENSRNOP00000090230.2, ENSRNOT00000116589.2
XM_039083979.2 → XP_038939907.1 DIS3-like exonuclease 2 isoform X1

UniProtKB/TrEMBL

A0A0G2K6W6, A6JWJ8

Conserved Domains (2) summary

COG0557
Location:238 → 824

VacB; Exoribonuclease R [Transcription]

pfam17216
Location:50 → 159

Rrp44_CSD1; Rrp44-like cold shock domain
XM_063267517.1 → XP_063123587.1 DIS3-like exonuclease 2 isoform X2

UniProtKB/TrEMBL

A6JWJ9, D3ZIL9
XM_039083981.2 → XP_038939909.1 DIS3-like exonuclease 2 isoform X5

UniProtKB/TrEMBL

A6JWK0

Conserved Domains (1) summary

COG0557
Location:37 → 623

VacB; Exoribonuclease R [Transcription]