Cltb clathrin, light chain B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cltbprovided by RGD
Official Full Name: clathrin, light chain Bprovided by RGD
Primary source: RGD:621353
See related: EnsemblRapid:ENSRNOG00000017506 AllianceGenome:RGD:621353
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables peptide binding activity. Involved in synaptic vesicle endocytosis. Part of clathrin coat. Is active in presynaptic endocytic zone membrane and synaptic vesicle membrane. Orthologous to human CLTB (clathrin light chain B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 895.4), Brain (RPKM 425.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (10006416..10024278)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (10001512..10019201)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (10537348..10554999)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE105422 (e-PCR)
- UniSTS:245836

CLTB_4592 (e-PCR)
- UniSTS:462817

BE110258 (e-PCR)
- UniSTS:245221

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables clathrin heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables neurotransmitter transmembrane transporter activity	NAS Non-traceable Author Statement more info	PubMed
enables peptide binding	IDA Inferred from Direct Assay more info	PubMed
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in clathrin-dependent endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter secretion	NAS Non-traceable Author Statement more info	PubMed
involved_in neurotransmitter transport	NAS Non-traceable Author Statement more info	PubMed
involved_in synaptic vesicle coating	NAS Non-traceable Author Statement more info	PubMed
involved_in synaptic vesicle endocytosis	EXP Inferred from Experiment more info	PubMed
involved_in synaptic vesicle endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle endocytosis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in ciliary membrane	ISO Inferred from Sequence Orthology more info
part_of clathrin coat	IDA Inferred from Direct Assay more info	PubMed
part_of clathrin coat of coated pit	NAS Non-traceable Author Statement more info	PubMed
part_of clathrin coat of trans-Golgi network vesicle	IEA Inferred from Electronic Annotation more info
part_of clathrin vesicle coat	IBA Inferred from Biological aspect of Ancestor more info
part_of clathrin vesicle coat	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic endocytic zone cytoplasmic component	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic endocytic zone membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: clathrin light chain B

Names: clathrin, light chain (Lcb); clathrin, light polypeptide (Lcb); lcb

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.