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    Slc20a2 solute carrier family 20 member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29502, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc20a2provided by RGD
    Official Full Name
    solute carrier family 20 member 2provided by RGD
    Primary source
    RGD:3699
    See related
    EnsemblRapid:ENSRNOG00000019490 AllianceGenome:RGD:3699
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ram1; Glvr2; Pit-2; RAM-1; Ab1-188
    Summary
    Enables sodium:phosphate symporter activity. Predicted to be involved in phosphate ion transmembrane transport and positive regulation of bone mineralization. Located in apical plasma membrane and brush border membrane. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human SLC20A2 (solute carrier family 20 member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 231.6), Liver (RPKM 124.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc20a2 in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (76163315..76253881, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (69460850..69551418, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (74318287..74408030, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene dickkopf WNT signaling pathway inhibitor 4 Neighboring gene voltage-dependent anion channel 3 like 1 Neighboring gene voltage-dependent anion channel 3 Neighboring gene uncharacterized LOC120097400 Neighboring gene small integral membrane protein 19 Neighboring gene uncharacterized LOC120097532 Neighboring gene mitochondrial ribosomal protein S31 Neighboring gene solute carrier family 25 member 15 Neighboring gene lncRNA derived from hepatocytes

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Na+-Pi cotransporter PiT-2 (SLC20A2) is expressed in the apical membrane of rat renal proximal tubules and regulated by dietary Pi. Villa-Bellosta R, et al. Am J Physiol Renal Physiol, 2009 Apr. PMID 19073637, Free PMC Article
    2. Extracellular inorganic phosphate regulates gibbon ape leukemia virus receptor-2/phosphate transporter mRNA expression in rat bone marrow stromal cells. Wada K, et al. J Cell Physiol, 2004 Jan. PMID 14584042
    3. Cloning of the cellular receptor for amphotropic murine retroviruses reveals homology to that for gibbon ape leukemia virus. Miller DG, et al. Proc Natl Acad Sci U S A, 1994 Jan 4. PMID 8278411, Free PMC Article
    4. Compensatory regulation of the sodium/phosphate cotransporters NaPi-IIc (SCL34A3) and Pit-2 (SLC20A2) during Pi deprivation and acidosis. Villa-Bellosta R, et al. Pflugers Arch, 2010 Feb. PMID 19841935
    5. Characterization of phosphate transport in rat vascular smooth muscle cells: implications for vascular calcification. Villa-Bellosta R, et al. Arterioscler Thromb Vasc Biol, 2007 May. PMID 17322102

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. expression in renal brush border reduced by parathyroid hormone
      Title: Acute parathyroid hormone differentially regulates renal brush border membrane phosphate cotransporters.
    2. Results describe the regulation of the sodium/phosphate cotransporters SCL34A3 and SLC20A2 during phosphate deprivation and acidosis in rat kidney.
      Title: Compensatory regulation of the sodium/phosphate cotransporters NaPi-IIc (SCL34A3) and Pit-2 (SLC20A2) during Pi deprivation and acidosis.
    3. Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency.
      Title: Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency.
    4. The Na+-Pi cotransporter PiT-2 (SLC20A2) is expressed in the apical membrane of rat renal proximal tubules and regulated by dietary Pi.
      Title: The Na+-Pi cotransporter PiT-2 (SLC20A2) is expressed in the apical membrane of rat renal proximal tubules and regulated by dietary Pi.
    5. We have used RNA interference to demonstrate that Pit1 and Pit2 are the transporters responsible for Na-dependent Pi transport in VSMCs.
      Title: Characterization of phosphate transport in rat vascular smooth muscle cells: implications for vascular calcification.
    6. mRNA expression level of Glvr-2 was increased by the addition of inorganic phosphate (Pi) in bone marrow stromal cells
      Title: Extracellular inorganic phosphate regulates gibbon ape leukemia virus receptor-2/phosphate transporter mRNA expression in rat bone marrow stromal cells.
    7. PiT-1 (Slc20a1) and PiT-2 (Slc20a2) were detected at the basolateral membrane of hepatocytes.
      Title: Identification and localization of sodium-phosphate cotransporters in hepatocytes and cholangiocytes of rat liver.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium:phosphate symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sodium:phosphate symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables virus receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphate ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphate ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of bone mineralization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in brush border membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sodium-dependent phosphate transporter 2
    Names
    gibbon ape leukemia virus receptor 2
    phosphate transporter 2
    receptor for amphitropic viruses 1
    receptor for amphotropic viruses 1
    solute carrier family 20 (phosphate transporter), member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017223.2 → NP_058919.1  sodium-dependent phosphate transporter 2

      See identical proteins and their annotated locations for NP_058919.1

      Status: PROVISIONAL

      Source sequence(s)
      BC070908
      UniProtKB/Swiss-Prot
      Q63488
      Related
      ENSRNOP00000026418.7, ENSRNOT00000026418.9
      Conserved Domains (1) summary
      pfam01384
      Location:478 → 638
      PHO4; Phosphate transporter family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      76163315..76253881 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094428.2 → XP_038950356.1  sodium-dependent phosphate transporter 2 isoform X1

      UniProtKB/Swiss-Prot
      Q63488
      Conserved Domains (1) summary
      pfam01384
      Location:478 → 638
      PHO4; Phosphate transporter family

    2. XM_008771352.4 → XP_008769574.1  sodium-dependent phosphate transporter 2 isoform X1

      See identical proteins and their annotated locations for XP_008769574.1

      UniProtKB/Swiss-Prot
      Q63488
      Conserved Domains (1) summary
      pfam01384
      Location:478 → 638
      PHO4; Phosphate transporter family

    3. XM_008771351.4 → XP_008769573.1  sodium-dependent phosphate transporter 2 isoform X1

      See identical proteins and their annotated locations for XP_008769573.1

      UniProtKB/Swiss-Prot
      Q63488
      Conserved Domains (1) summary
      pfam01384
      Location:478 → 638
      PHO4; Phosphate transporter family

    4. XM_017600054.3 → XP_017455543.1  sodium-dependent phosphate transporter 2 isoform X1

      UniProtKB/Swiss-Prot
      Q63488
      Conserved Domains (1) summary
      pfam01384
      Location:478 → 638
      PHO4; Phosphate transporter family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63488.1 GenPept UniProtKB/Swiss-Prot:Q63488

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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