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    Sbp spermine binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25540, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sbpprovided by RGD
    Official Full Name
    spermine binding proteinprovided by RGD
    Primary source
    RGD:3623
    See related
    EnsemblRapid:ENSRNOG00000058058 AllianceGenome:RGD:3623
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zg16b
    Summary
    Predicted to enable polyamine binding activity. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Sbp in Genome Data Viewer
    Location:
    10q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (13450613..13473016)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (12946036..12968439)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (13289502..13309338)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene serine protease 21 Neighboring gene common salivary protein 1 Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene uncharacterized LOC120095045 Neighboring gene zymogen granule protein 16B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Prostatic spermine-binding protein. Cloning and nucleotide sequence of cDNA, amino acid sequence, and androgenic control of mRNA level. Chang CS, et al. J Biol Chem, 1987 Feb 25. PMID 3818623
    2. Correction of the cDNA-derived protein sequence of prostatic spermine binding protein: pivotal role of tandem mass spectrometry in sequence analysis. Anderegg RJ, et al. Biochemistry, 1988 Jun 14. PMID 3166977
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polyamine binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    prostatic spermine-binding protein
    Names
    zymogen granule protein 16B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309360.1 → NP_001296289.1  prostatic spermine-binding protein isoform 2

      See identical proteins and their annotated locations for NP_001296289.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.
      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0G2K4C9, A6HCN9
      Conserved Domains (1) summary
      cd09611
      Location:110 → 205
      Jacalin_ZG16_like; Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins

    2. NM_001399302.1 → NP_001386231.1  prostatic spermine-binding protein isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0G2K176, A6HCP0
      Conserved Domains (1) summary
      cd09611
      Location:22 → 150
      Jacalin_ZG16_like; Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins

    3. NM_013024.4 → NP_037156.3  prostatic spermine-binding protein isoform 1 precursor

      See identical proteins and their annotated locations for NP_037156.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0G2K176, A6HCP0
      Related
      ENSRNOP00000071728.1, ENSRNOT00000083075.3
      Conserved Domains (1) summary
      cd09611
      Location:22 → 150
      Jacalin_ZG16_like; Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      13450613..13473016
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08723.1 GenPept UniProtKB/Swiss-Prot:P08723

    Gene LinkOut

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