Scd stearoyl-CoA desaturase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Scdprovided by RGD
Official Full Name: stearoyl-CoA desaturaseprovided by RGD
Primary source: RGD:621176
See related: EnsemblRapid:ENSRNOG00000013552 AllianceGenome:RGD:621176
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Scd1
Summary: Enables iron ion binding activity and stearoyl-CoA 9-desaturase activity. Involved in response to fatty acid; response to nutrient; and unsaturated fatty acid biosynthetic process. Located in membrane. Used to study carcinoma. Biomarker of hyperinsulinism; metabolic dysfunction-associated steatohepatitis; and metabolic dysfunction-associated steatotic liver disease. Orthologous to human SCD (stearoyl-CoA desaturase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 4781.4), Adrenal (RPKM 4523.2) and 5 other tissues See more
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Genomic context

Location:: 1q54

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (253218968..253232101, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (243269745..243282878, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (264159966..264173061, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of LBP triggers lipid metabolic disorder through H3K27 acetylation-mediated C/EBPbeta- SCD activation in non-alcoholic fatty liver disease.
Title: Loss of LBP triggers lipid metabolic disorder through H3K27 acetylation-mediated C/EBPβ- SCD activation in non-alcoholic fatty liver disease.
Investigated the effects of maternal high fat diet on milk compostion, offspring adipose tissue and epigenetic regulation of adipose tissue stearoyl-CoA desaturase-1 (SCD1) in suckling offspring.
Title: Maternal high-fat diet during suckling programs visceral adiposity and epigenetic regulation of adipose tissue stearoyl-CoA desaturase-1 in offspring.
Feeding of VAD diet either alone or under HFr condition increased the kidney oleic acid (C18:1) levels and thus total MUFA, which corroborated with elevated SCD1 activity index, without affecting its expression status
Title: Vitamin A deficiency increases the oleic acid (C18:1) levels in the kidney of high fructose diet-fed rats.
Study in non-alcoholic fatty liver disease model in rats demonstrates that miR-192-5p has a negative regulatory role in lipid synthesis, which is mediated through its direct regulation of SCD-1.
Title: miR-192-5p regulates lipid synthesis in non-alcoholic fatty liver disease through SCD-1.
SCD1 overexpression in fatty liver disease is not affected by fasting after long-term fructose consumption in rats. Regulation of SCD1 plays an important role in fructose-induced hepatic steatosis.
Title: Long-term fructose consumption prolongs hepatic stearoyl-CoA desaturase 1 activity independent of upstream regulation in rats.
Authors investigated whether SCD1 activity is engaged in palmitate-induced pancreatic beta-cell autophagy
Title: Inhibition of SCD1 impairs palmitate-derived autophagy at the step of autophagosome-lysosome fusion in pancreatic β-cells.
SCD1 activity and SCD1 gene expression were considerably up-regulated in Goto-Kakizaki rats, and these levels were largely comparable to those in obese Zucker (fa/fa) rats.
Title: Up-regulation of stearoyl-CoA desaturase 1 increases liver MUFA content in obese Zucker but not Goto-Kakizaki rats.
Adipose tissue stearoyl-CoA desaturase 1 index is increased in obesity-prone rats fed a high-fat diet.
Title: Adipose tissue stearoyl-CoA desaturase 1 index is increased and linoleic acid is decreased in obesity-prone rats fed a high-fat diet.
Data suggest that down-regulation of stearoyl-CoA desaturase Scd1 is a mechanism by which n-3 fatty acids repress constitutive triglyceride biosynthesis.
Title: Omega-3 fatty acid deficiency increases stearoyl-CoA desaturase expression and activity indices in rat liver: positive association with non-fasting plasma triglyceride levels.
increased expression genes encoding Scd1, Elovl6, and other key lipogenic enzymes may favor fat storage after chronic food restriction/refeeding and may be part of the molecular mechanism by which food restriction/refeeding increases body weight
Title: Up-regulation of stearoyl-CoA desaturase 1 and elongase 6 genes expression in rat lipogenic tissues by chronic food restriction and chronic food restriction/refeeding.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:498485 (e-PCR)
- UniSTS:498485

Scd1 (e-PCR), detects polymorphism
- UniSTS:498485

Scd1 (e-PCR), detects polymorphism
- UniSTS:461929

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables iron ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables iron ion binding	IDA Inferred from Direct Assay more info	PubMed
enables iron ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables palmitoyl-CoA 9-desaturase activity	IBA Inferred from Biological aspect of Ancestor more info
enables palmitoyl-CoA 9-desaturase activity	ISO Inferred from Sequence Orthology more info
enables stearoyl-CoA 9-desaturase activity	IBA Inferred from Biological aspect of Ancestor more info
enables stearoyl-CoA 9-desaturase activity	IDA Inferred from Direct Assay more info	PubMed
enables stearoyl-CoA 9-desaturase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables stearoyl-CoA 9-desaturase activity	ISO Inferred from Sequence Orthology more info
enables stearoyl-CoA 9-desaturase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in lipid biosynthetic process	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within lipid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in monounsaturated fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monounsaturated fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in monounsaturated fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to fatty acid	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to fatty acid	IDA Inferred from Direct Assay more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in sebaceous gland development	ISO Inferred from Sequence Orthology more info
involved_in sterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in tarsal gland development	ISO Inferred from Sequence Orthology more info
involved_in triglyceride metabolic process	ISO Inferred from Sequence Orthology more info
involved_in unsaturated fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in unsaturated fatty acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in unsaturated fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in unsaturated fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within white fat cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acyl-CoA desaturase 1

Names: delta(9)-desaturase 1; fatty acid desaturase 1; stearoyl-CoA desaturase 1; stearoyl-Coenzyme A desaturase 1

NP_631931.2

EC 1.14.19.1

XP_006231495.1

EC 1.14.19.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139192.2 → NP_631931.2 acyl-CoA desaturase 1

See identical proteins and their annotated locations for NP_631931.2

Status: PROVISIONAL

Source sequence(s)

AF509569

UniProtKB/Swiss-Prot

P07308, Q8JZL5

UniProtKB/TrEMBL

A6JHF3, A6JHF9

Related

ENSRNOP00000018447.3, ENSRNOT00000018447.7

Conserved Domains (2) summary

cd03505
Location:99 → 336

Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...

pfam00487
Location:100 → 305

FA_desaturase; Fatty acid desaturase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

253218968..253232101 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006231433.3 → XP_006231495.1 acyl-CoA desaturase 1 isoform X1

See identical proteins and their annotated locations for XP_006231495.1

UniProtKB/Swiss-Prot

P07308, Q8JZL5

UniProtKB/TrEMBL

A6JHF3, A6JHF9

Conserved Domains (2) summary

cd03505
Location:99 → 336

Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...

pfam00487
Location:100 → 305

FA_desaturase; Fatty acid desaturase