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    Cdc7 cell division cycle 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360908, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cdc7provided by RGD
    Official Full Name
    cell division cycle 7provided by RGD
    Primary source
    RGD:1308351
    See related
    EnsemblRapid:ENSRNOG00000002105 AllianceGenome:RGD:1308351
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including cell cycle phase transition; double-strand break repair via break-induced replication; and positive regulation of cell cycle process. Predicted to be located in intercellular bridge; mitotic spindle; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human CDC7 (cell division cycle 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 39.4), Spleen (RPKM 37.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdc7 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (2949538..2969656, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (2804660..2824796, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (3826658..3846891, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550678 Neighboring gene uncharacterized LOC120096508 Neighboring gene transmembrane protein 258 like 3 Neighboring gene helicase for meiosis 1 Neighboring gene uncharacterized LOC134481813

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cdc7 kinase stimulates Aurora B kinase in M-phase. Ito S, et al. Sci Rep, 2019 Dec 9. PMID 31819079, Free PMC Article
    2. A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases. Yoshizawa-Sugata N, et al. J Biol Chem, 2005 Apr 1. PMID 15668232
    3. Drf1, a novel regulatory subunit for human Cdc7 kinase. Montagnoli A, et al. EMBO J, 2002 Jun 17. PMID 12065429, Free PMC Article
    4. Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint. Yoshizawa-Sugata N, et al. J Biol Chem, 2007 Jan 26. PMID 17102137
    5. Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7. Sato N, et al. EMBO J, 1997 Jul 16. PMID 9250678, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cdc7 kinase stimulates Aurora B kinase in M-phase.
      Title: Cdc7 kinase stimulates Aurora B kinase in M-phase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of nuclear cell cycle DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cell division cycle 7-related protein kinase
    Names
    cell division cycle 7 homolog
    NP_001101822.1
    XP_008768162.1
    XP_017454768.1
    XP_017454769.1
    XP_063129390.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108352.1 → NP_001101822.1  cell division cycle 7-related protein kinase

      See identical proteins and their annotated locations for NP_001101822.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474079
      UniProtKB/TrEMBL
      A6KPK3, D4A8S5
      Related
      ENSRNOP00000059094.1, ENSRNOT00000068520.3
      Conserved Domains (2) summary
      cd14019
      Location:52 → 461
      STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
      cl21453
      Location:372 → 562
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      2949538..2969656 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017599280.3 → XP_017454769.1  cell division cycle 7-related protein kinase isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZQV6
      Related
      ENSRNOP00000080895.1, ENSRNOT00000101926.2
      Conserved Domains (3) summary
      cd14019
      Location:52 → 429
      STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
      pfam00069
      Location:52 → 410
      Pkinase; Protein kinase domain
      cl21453
      Location:340 → 530
      PKc_like; Protein Kinases, catalytic domain

    2. XM_017599279.3 → XP_017454768.1  cell division cycle 7-related protein kinase isoform X1

      UniProtKB/TrEMBL
      A6KPK3, D4A8S5
      Conserved Domains (2) summary
      cd14019
      Location:52 → 461
      STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
      cl21453
      Location:372 → 562
      PKc_like; Protein Kinases, catalytic domain

    3. XM_063273320.1 → XP_063129390.1  cell division cycle 7-related protein kinase isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZQV6

    4. XM_008769940.3 → XP_008768162.1  cell division cycle 7-related protein kinase isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:1 → 350
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_010057384.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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