Sult1b1 sulfotransferase family 1B member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sult1b1provided by RGD
Official Full Name: sulfotransferase family 1B member 1provided by RGD
Primary source: RGD:708534
See related: EnsemblRapid:ENSRNOG00000001967 AllianceGenome:RGD:708534
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ST1B1
Summary: Enables aryl sulfotransferase activity. Involved in sulfation and thyroid hormone metabolic process. Predicted to be active in cytoplasm. Orthologous to human SULT1B1 (sulfotransferase family 1B member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 1763.7) See more
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Genomic context

Location:: 14p21

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (20771917..20784665)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (20492763..20505491)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (22142412..22155246)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Both fipronil and fipronil sulfone treatments induced a 2.5-fold increase in Ugt1a1 and Sult1b1 messenger RNA (mRNA) expressions.
Title: CYP450-dependent biotransformation of the insecticide fipronil into fipronil sulfone can mediate fipronil-induced thyroid disruption in rats.
importance of these enzymes for the sulfation of iodothyronines in rat liver, with a greater contribution of in male than in female liver and it also contributes to iodothyronine sulfation in rat kidney
Title: Characterization of rat iodothyronine sulfotransferases.
Chinese hamster V79-derived cell lines (V79-rSULT1B1-A and -B) that express rat sulfotransferase 1B1 (rSULT1B1) activated promutagenic benzylic alcohols into mutagens with more than 100-fold cytotoxicity.
Title: Stable expression of rat sulfotransferase 1B1 in V79 cells: activation of benzylic alcohols to mutagens.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aryl sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aryl sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables aryl sulfotransferase activity	ISO Inferred from Sequence Orthology more info
enables sulfotransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in ethanol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in flavonoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phenol-containing compound metabolic process	ISO Inferred from Sequence Orthology more info
involved_in sulfation	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sulfation	ISO Inferred from Sequence Orthology more info
involved_in sulfation	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in thyroid hormone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sulfotransferase 1B1

Names: dopa/tyrosine sulfotransferase; sulfotransferase family, cytosolic, 1B, member 1

NP_071958.1

EC 2.8.2.1

XP_008768278.1

EC 2.8.2.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022513.2 → NP_071958.1 sulfotransferase 1B1

See identical proteins and their annotated locations for NP_071958.1

Status: PROVISIONAL

Source sequence(s)

U38419

UniProtKB/Swiss-Prot

P52847

UniProtKB/TrEMBL

A6KU26

Related

ENSRNOP00000101178.1, ENSRNOT00000134618.1

Conserved Domains (1) summary

pfam00685
Location:40 → 289

Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

20771917..20784665

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008770056.4 → XP_008768278.1 sulfotransferase 1B1 isoform X1

UniProtKB/Swiss-Prot

P52847

UniProtKB/TrEMBL

A6KU26

Related

ENSRNOP00000002699.3, ENSRNOT00000002699.7

Conserved Domains (1) summary

pfam00685
Location:20 → 261

Sulfotransfer_1; Sulfotransferase domain