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    Gna12 G protein subunit alpha 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81663, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gna12provided by RGD
    Official Full Name
    G protein subunit alpha 12provided by RGD
    Primary source
    RGD:71018
    See related
    EnsemblRapid:ENSRNOG00000001235 AllianceGenome:RGD:71018
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hg1m1
    Summary
    Enables D5 dopamine receptor binding activity. Involved in response to xenobiotic stimulus. Acts upstream of or within G protein-coupled receptor signaling pathway; negative regulation of vascular associated smooth muscle cell migration; and negative regulation of vascular associated smooth muscle cell proliferation. Located in brush border membrane. Orthologous to human GNA12 (G protein subunit alpha 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 377.5), Heart (RPKM 344.9) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gna12 in Genome Data Viewer
    Location:
    12q11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (18919629..19000185)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (13805580..13886255)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (15890202..15971212)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547234 Neighboring gene caspase recruitment domain family, member 11 Neighboring gene archaelysin family metallopeptidase 1 Neighboring gene BRCA1-associated ATM activator 1 Neighboring gene IQ motif containing E

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables D5 dopamine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables D5 dopamine receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables G protein activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables G-protein beta/gamma-subunit complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein phosphatase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled dopamine receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic digit morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of TOR signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of fibroblast migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in brush border membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in brush border membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of heterotrimeric G-protein complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    guanine nucleotide-binding protein subunit alpha-12
    Names
    g alpha-12
    guanine nucleotide binding protein (G protein) alpha 12
    guanine nucleotide binding protein, alpha 12
    heterotrimeric guanine nucleotide-binding protein 1m1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031034.2NP_112296.1  guanine nucleotide-binding protein subunit alpha-12

      See identical proteins and their annotated locations for NP_112296.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q63210
      UniProtKB/TrEMBL
      Q45QM2, Q45QM3
      Related
      ENSRNOP00000001654.5, ENSRNOT00000001654.9
      Conserved Domains (1) summary
      smart00275
      Location:40377
      G_alpha; G protein alpha subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      18919629..19000185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)