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    Rgs19 regulator of G-protein signaling 19 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 59293, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rgs19provided by RGD
    Official Full Name
    regulator of G-protein signaling 19provided by RGD
    Primary source
    RGD:629471
    See related
    EnsemblRapid:ENSRNOG00000016547 AllianceGenome:RGD:629471
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gaip; Camki
    Summary
    Enables G-protein alpha-subunit binding activity. Involved in response to ethanol. Located in brush border and clathrin-coated vesicle. Orthologous to human RGS19 (regulator of G protein signaling 19). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 46.3), Thymus (RPKM 45.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rgs19 in Genome Data Viewer
    Location:
    3q43
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (189182041..189190494, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168804532..168813035, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (177196276..177204767, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101835 Neighboring gene transcription elongation factor A2 Neighboring gene LKAAEAR motif containing 1 Neighboring gene opioid related nociceptin receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RGS-GAIP, a GTPase-activating protein for Galphai heterotrimeric G proteins, is located on clathrin-coated vesicles. De Vries L, et al. Mol Biol Cell, 1998 May. PMID 9571244, Free PMC Article
    2. Chronic intermittent ethanol exposure selectively alters the expression of Gα subunit isoforms and RGS subtypes in rat prefrontal cortex. Luessen DJ, et al. Brain Res, 2017 Oct 1. PMID 28736108, Free PMC Article
    3. FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions. Serezani CH, et al. Blood, 2009 Oct 8. PMID 19657115, Free PMC Article
    4. Membrane-associated GAIP is a phosphoprotein and can be phosphorylated by clathrin-coated vesicles. Fischer T, et al. Proc Natl Acad Sci U S A, 2000 Apr 11. PMID 10760275, Free PMC Article
    5. GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function. Lou X, et al. J Am Soc Nephrol, 2002 Apr. PMID 11912251

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108699

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G-protein alpha-subunit binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables myosin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to interleukin-7 ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within glutamate secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in presynaptic modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein targeting ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    regulator of G-protein signaling 19
    Names
    G alpha interacting protein
    calcium/calmodulin-dependent protein kinase I
    regulator of G-protein signalling 19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429113.1 → NP_001416042.1  regulator of G-protein signaling 19

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      O70521
      UniProtKB/TrEMBL
      A6KLX5

    2. NM_021661.3 → NP_067693.1  regulator of G-protein signaling 19

      See identical proteins and their annotated locations for NP_067693.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      O70521
      UniProtKB/TrEMBL
      A6KLX5
      Related
      ENSRNOP00000022451.4, ENSRNOT00000022451.6
      Conserved Domains (1) summary
      cl02565
      Location:87 → 204
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    RNA

    1. NR_190577.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      189182041..189190494 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284434.1 → XP_063140504.1  regulator of G-protein signaling 19 isoform X3

    2. XM_006235801.5 → XP_006235863.3  regulator of G-protein signaling 19 isoform X1

    3. XM_008762541.4 → XP_008760763.1  regulator of G-protein signaling 19 isoform X4

      See identical proteins and their annotated locations for XP_008760763.1

      UniProtKB/TrEMBL
      A6KLX9
      Related
      ENSRNOP00000099010.1, ENSRNOT00000174086.1
      Conserved Domains (1) summary
      cl02565
      Location:65 → 182
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    4. XM_008762540.4 → XP_008760762.1  regulator of G-protein signaling 19 isoform X4

      See identical proteins and their annotated locations for XP_008760762.1

      UniProtKB/TrEMBL
      A6KLX9
      Conserved Domains (1) summary
      cl02565
      Location:65 → 182
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    5. XM_063284433.1 → XP_063140503.1  regulator of G-protein signaling 19 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70521.1 GenPept UniProtKB/Swiss-Prot:O70521

    Gene LinkOut

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