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    Kcnh7 potassium voltage-gated channel subfamily H member 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170739, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Kcnh7provided by RGD
    Official Full Name
    potassium voltage-gated channel subfamily H member 7provided by RGD
    Primary source
    RGD:621112
    See related
    EnsemblRapid:ENSRNOG00000007528 AllianceGenome:RGD:621112
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    erg3
    Summary
    Enables inward rectifier potassium channel activity. Involved in circadian rhythm and potassium ion transport. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Orthologous to human KCNH7 (potassium voltage-gated channel subfamily H member 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 126.3), Kidney (RPKM 7.2) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kcnh7 in Genome Data Viewer
    Location:
    3q21
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (67737900..68230950, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (47329338..47822122, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (48662450..49168716, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene SHOC2 leucine-rich repeat scaffold protein, pseudogene 1 Neighboring gene interferon induced with helicase C domain 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene grancalcin Neighboring gene uncharacterized LOC108350383 Neighboring gene uncharacterized LOC134486366

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A single amino acid difference between ether-a-go-go- related gene channel subtypes determines differential sensitivity to a small molecule activator. Perry M, et al. Mol Pharmacol, 2008 Apr. PMID 18162604, Free PMC Article
    2. Circadian changes of ether-a-go-go-related-gene (Erg) potassium channel transcripts in the rat pancreas and beta-cell. Mühlbauer E, et al. Cell Mol Life Sci, 2007 Mar. PMID 17322986, Free PMC Article
    3. Rat liver carboxylesterase: cDNA cloning, sequencing, and evidence for a multigene family. Long RM, et al. Biochem Biophys Res Commun, 1988 Oct 31. PMID 2973315
    4. Fast erg K+ currents in rat embryonic serotonergic neurones. Hirdes W, et al. J Physiol, 2005 Apr 1. PMID 15677682, Free PMC Article
    5. Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers. Wimmers S, et al. Pflugers Arch, 2001 Jan. PMID 11212207

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The differential sensitivity of hERG1 and rERG3 channels to the agonist effect of RPR could be accounted for by a single S5 residue (Thr556 in hERG1, Ile558 in rERG3).
      Title: A single amino acid difference between ether-a-go-go- related gene channel subtypes determines differential sensitivity to a small molecule activator.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inward rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inward rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables voltage-gated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    voltage-gated inwardly rectifying potassium channel KCNH7; potassium voltage-gated channel subfamily H member 7
    Names
    ERG-3
    eag-related protein 3
    ether-a-go-go-related gene potassium channel 3
    ether-a-go-go-related protein 3
    potassium channel erg3
    potassium channel, voltage gated eag related subfamily H, member 7
    potassium voltage-gated channel, subfamily H (eag-related), member 7
    voltage-gated potassium channel subunit Kv11.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131912.1 → NP_571987.1  voltage-gated inwardly rectifying potassium channel KCNH7

      See identical proteins and their annotated locations for NP_571987.1

      Status: PROVISIONAL

      Source sequence(s)
      AF016191
      UniProtKB/Swiss-Prot
      O54852
      UniProtKB/TrEMBL
      A0A8I5ZLI3, A6HLW2
      Related
      ENSRNOP00000078968.2, ENSRNOT00000119314.2
      Conserved Domains (6) summary
      COG0664
      Location:739 → 869
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:745 → 856
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00130
      Location:41 → 130
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00520
      Location:448 → 671
      Ion_trans; Ion transport protein
      pfam07885
      Location:614 → 668
      Ion_trans_2; Ion channel
      pfam13426
      Location:29 → 134
      PAS_9; PAS domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      67737900..68230950 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283033.1 → XP_063139103.1  potassium voltage-gated channel subfamily H member 7 isoform X4

      Related
      ENSRNOP00000078922.2, ENSRNOT00000112058.2

    2. XM_063283031.1 → XP_063139101.1  potassium voltage-gated channel subfamily H member 7 isoform X3

      Related
      ENSRNOP00000072574.3, ENSRNOT00000085246.3

    3. XM_017591438.3 → XP_017446927.1  potassium voltage-gated channel subfamily H member 7 isoform X2

      UniProtKB/TrEMBL
      A0A0H2UHF2

    4. XM_006234269.5 → XP_006234331.1  potassium voltage-gated channel subfamily H member 7 isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHF2
      Related
      ENSRNOP00000009920.6, ENSRNOT00000009920.6
      Conserved Domains (6) summary
      COG0664
      Location:747 → 877
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:753 → 864
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00130
      Location:41 → 130
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00520
      Location:456 → 679
      Ion_trans; Ion transport protein
      pfam07885
      Location:622 → 676
      Ion_trans_2; Ion channel
      pfam13426
      Location:29 → 134
      PAS_9; PAS domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54852.1 GenPept UniProtKB/Swiss-Prot:O54852

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