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    Best3 Bestrophin 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39661, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Best3provided by FlyBase
    Official Full Name
    Bestrophin 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0036492
    Locus tag
    Dmel_CG12327
    See related
    AllianceGenome:FB:FBgn0036492
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12327; dbest3; dBest3; Dmel\CG12327
    Summary
    Predicted to enable chloride channel activity. Predicted to be involved in chloride transport. Predicted to be located in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in autosomal dominant vitreoretinochoroidopathy; bestrophinopathy; macular degeneration; retinitis pigmentosa 50; and vitelliform macular dystrophy. Orthologous to several human genes including BEST2 (bestrophin 2) and BEST4 (bestrophin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Best3 in Genome Data Viewer
    Location:
    71C2-71C2; 3-43 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15300915..15302785, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15294015..15295885, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Peroxiredoxin 1 Neighboring gene tollo Neighboring gene Bestrophin 4 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46213

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dbest1, a Drosophila homolog of human Bestrophin, is not required for viability or photoreceptor integrity. Tavsanli BC, et al. Genesis, 2001 Nov. PMID 11747204
    2. Drosophila bestrophin-1 chloride current is dually regulated by calcium and cell volume. Chien LT, et al. J Gen Physiol, 2007 Nov. PMID 17968025, Free PMC Article
    3. Molecular physiology of bestrophins: multifunctional membrane proteins linked to best disease and other retinopathies. Hartzell HC, et al. Physiol Rev, 2008 Apr. PMID 18391176
    4. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chloride channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    bestrophin 3
    Names
    Best3-PA
    CG12327-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15300915..15302785 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168618.2 → NP_730039.1  bestrophin 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730039.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUM7
      Related
      FBpp0075371
      Conserved Domains (1) summary
      pfam01062
      Location:8 → 319
      Bestrophin; Bestrophin, RFP-TM, chloride channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VUM7 Q9VUM7

    Gene LinkOut

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