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    Pgi Phosphoglucose isomerase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35886, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Pgiprovided by FlyBase
    Official Full Name
    Phosphoglucose isomeraseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003074
    Locus tag
    Dmel_CG8251
    See related
    AllianceGenome:FB:FBgn0003074
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8251; Dmel\CG8251; DmG6PI; gpi; Gpi; GPI; pgi; PGI
    Summary
    Enables glucose-6-phosphate isomerase activity. Involved in several processes, including canonical glycolysis; fructose 6-phosphate metabolic process; and glucose 6-phosphate metabolic process. Located in cytosol. Is expressed in several structures, including adult head; adult heart; larval muscle system; larval somatic muscle cell; and spermatozoon. Used to study heart disease. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; congenital nonspherocytic hemolytic anemia; intellectual disability; and neuromuscular disease. Orthologous to human GPI (glucose-6-phosphate isomerase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pgi in Genome Data Viewer
    Location:
    44F6-44F6; 2-59 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8910900..8914069, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4798405..4801574, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Chaperonin containing TCP1 subunit 8 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene lines Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Spitting Image

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Autosomal factors with correlated effects on the activities of the glucose 6-phosphate and 6-phosphogluconate dehydrogenases in Drosophila melanogaster. Laurie-Ahlberg CC, et al. Genetics, 1981 Sep. PMID 6804300, Free PMC Article
    2. Glucose-6-phosphate isomerase is necessary for embryo implantation in the domestic ferret. Schulz LC, et al. Proc Natl Acad Sci U S A, 2003 Jul 8. PMID 12826606, Free PMC Article
    3. The glycolytic enzyme, GPI, is a functionally conserved modifier of dopaminergic neurodegeneration in Parkinson's models. Knight AL, et al. Cell Metab, 2014 Jul 1. PMID 24882066, Free PMC Article
    4. Biochemical characterization of phosphoglucose isomerase and genetic variants from mouse and Drosophila melanogaster. Charles D, et al. Mol Cell Biochem, 1980 Jan 16. PMID 6767907
    5. A venom protein of ectoparasitoid Pachycrepoideus vindemiae, PvG6PDH, contributes to parasitism by inhibiting host glucose-6-phosphate metabolism. Yang L, et al. Insect Sci, 2022 Apr. PMID 34724344

    See all (150) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carbohydrate derivative binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucose-6-phosphate isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucose-6-phosphate isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glucose-6-phosphate isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucose-6-phosphate isomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables monosaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in canonical glycolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fructose 6-phosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gluconeogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glucose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucose 6-phosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphoglucose isomerase
    Names
    CG8251-PA
    CG8251-PB
    CG8251-PC
    Glucose-6-phosphate isomerase
    Pgi-PA
    Pgi-PB
    Pgi-PC
    glucose phosphate isomerase
    phosphoglucoisomerase
    NP_523663.1
    NP_724723.1
    NP_724724.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8910900..8914069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165635.2 → NP_724723.1  phosphoglucose isomerase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724723.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZ93, P52029, Q0E9F0, Q27868, Q27870, Q9V4Z8
      Related
      FBpp0087761
      Conserved Domains (3) summary
      PRK00179
      Location:7 → 556
      pgi; glucose-6-phosphate isomerase; Reviewed
      cd05015
      Location:128 → 290
      SIS_PGI_1; Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of ...
      cd05016
      Location:338 → 529
      SIS_PGI_2; Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of ...

    2. NM_078939.3 → NP_523663.1  phosphoglucose isomerase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523663.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZ93, P52029, Q0E9F0, Q27868, Q27870, Q9V4Z8
      Related
      FBpp0087760
      Conserved Domains (3) summary
      PRK00179
      Location:7 → 556
      pgi; glucose-6-phosphate isomerase; Reviewed
      cd05015
      Location:128 → 290
      SIS_PGI_1; Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of ...
      cd05016
      Location:338 → 529
      SIS_PGI_2; Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of ...

    3. NM_165636.2 → NP_724724.1  phosphoglucose isomerase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724724.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZ93, P52029, Q0E9F0, Q27868, Q27870, Q9V4Z8
      Related
      FBpp0087762
      Conserved Domains (3) summary
      PRK00179
      Location:7 → 556
      pgi; glucose-6-phosphate isomerase; Reviewed
      cd05015
      Location:128 → 290
      SIS_PGI_1; Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of ...
      cd05016
      Location:338 → 529
      SIS_PGI_2; Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52029.2 P52029

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